TUTKIMUS: LYHYT ANTIBIOOTTIKUURI EI RIITTÄVÄ

[Bb]

Lähettäjä: Soijuv Lähetetty: 14.6.2004 17:28

Puolalaisen tutkimuksen mukaan sytokiinipitoisuudet (IL-1, IL-6, TNF-alfa) pysyivät korkeana lyhyestä ab-hoidosta huolimatta. Tutkijat tulivat siihen tulokseen ettei lyhyt ab-hoito ei näytä olevan riittävä hoito borrelioosissa.


Effect of antibiotic therapy on levels of proinflammatory cytokines: interleukin IL-1, IL-6 and tumor necrosis factor TNF-alpha in serum of patients with Lyme borreliosis

Wiad Lek. 2002;55(5-6):276-81

[Article in Polish]

Kondrusik M, Swierzbinska R, Zajkowska JM, Pancewicz SA, Grygorczuk S, Hermanowska-Szpakowicz T.

Kliniki Chorob Zakaznych i Neuroinfekcji Akademii Medycznej w Bialymstoku.

We estimated serum concentrations of cytokines: IL-1, IL-6, TNF-alpha in patients with diagnosed Lyme disease treated for 14 days with antibiotics. The detection of proinflammatory cytokines was performed by ELISA tests. The examination was carried out before and after the treatment. The comparison with control group stated statistically significant higher concentration of IL-1, IL-6 and TNF-alpha before and after the treatment. Comparing the concentrations of cytokines after treatment with control group showed normalization only in a few cases. In the majority of cases serum cytokines concentrations remained significantly higher. That is why we conclude that 14-day-therapy with antibiotic in patients with Lyme disease may not be sufficient.

Publication Types:

· Clinical Trial

· Controlled Clinical Trial


PMID: 12235693 [PubMed - indexed for MEDLINE]