DOKSISYKLIINI - KALLON SISÄISEN PAINEEN NOUSU

[Bb]

Lähettäjä: Soijuv Lähetetty: 25.6.2004 10:36

Artikkelin mukaan doksisykliini aiheutti kallonsisäisen paineen nousua muutamilla potilailla. Sen seurauksena potilailla esiintyi näköhäiriöitä.


NEUROLOGY 2004;62:2297-2299
© 2004 American Academy of Neurology

Brief Communications
Doxycycline and intracranial hypertension

D. I. Friedman, MD, L. K. Gordon, MD PhD, R. A. Egan, MD, D. M. Jacobson, MD, H. Pomeranz, MD PhD,A. R. Harrison, MD and Y. Goldhammer, MD

From the Departments of Ophthalmology and Neurology (Dr. Friedman), University of Rochester School of Medicine and Dentistry, NY, Jules Stein Eye Institute (Dr. Gordon), David Geffen School of Medicine, University of California at Los Angeles, and Greater Los Angeles Veterans Administration Healthcare System, Casey Eye Institute (Dr. Egan), Departments of Ophthalmology and Neurology, Oregon Health and Science University, Portland, Department of Neurology (Dr. Jacobson), Marshfield Clinic, WI, Department of Ophthalmology (Drs. Pomeranz and Harrison), University of Minnesota, Minneapolis; and Department of Neurology (Dr. Goldhammer), Sheba Medical Center, Tel-Hashomer, Israel.

Address correspondence and reprint requests to Dr. D.I. Friedman, Department of Ophthalmology,University of Rochester601 Elmwood Ave., Box 659 Rochester 14642 e-mail: Deborah_Friedman@urmc.rochester.edu

The authors report seven patients from six neuro-ophthalmology referral centers who developed pseudo-tumor cerebri during treatment with doxycycline. All four female patients and one of three male patients were obese. Vision was minimally affected in most patients, but two had substantial visual acuity or visual field loss at presentation. Discontinuation of doxycycline, with or without additional intracranial pressure-lowering agents, yielded improvement, but permanent visual acuity or visual field loss occurred in five patients.

Received October 8, 2003. Accepted in final form February 23, 2004.

Seuraavassa on lyhyt selvitys pseudotumorista. Sairaus aiheuttaa samankaltaisia oireita kuin aivokasvain; esim. päänsärkyä, pahoinvointia, oksentelua jne:

Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure caused by the buildup or poor absorption of cerebrospinal fluid in the subarachnoid space surrounding the brain. The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating intracranial noises, closely mimic symptoms of brain tumors.