Lähettäjä: Soijuv Lähetetty: 20.7.2004 12:36
Alhainen estrogeenitaso saatta olla osasyynä esim reumasairauksissa seuraavan artikkelin mukaan. Estrogeeni vaikuttaa myös sytokiineihin, jotka ovat osallisina tiettyjen autoimmuunisairauksien synnyssä.
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Study Links Estrogen to Rheumatoid Arthritis
ProHealthNetwork.com
07-19-2004 Lab Findings May Have Implications for Other Autoimmune Diseases
By Salynn Boyles
WebMD Medical News
Reviewed By Michael Smith, MD
on Thursday, June 03, 2004
New research may help explain estrogen's role in rheumatoid arthritis and other autoimmune diseases that afflict women far more often than men.
Women with rheumatoid arthritis tend to have fewer symptoms during pregnancy, when estrogen levels are high. Symptoms tend to worsen after they give birth and at menopause, when levels are low. Although a link between the female sex hormone and the autoimmune disease has long been suspected, the clinical evidence has been contradictory.
In the newly published study, investigators from Dallas' Baylor College of Dentistry report that estrogen directly influences key inflammation-causing chemicals, known as cytokines, that drive certain autoimmune diseases.
In a laboratory study, the researchers investigated estrogen's connection to CD16, a molecule that regulates inflammation. They found that when estrogen levels were low, CD16 levels increased. The findings are reported in the June issue of the journal Arthritis and Rheumatism.
"This may be one mechanism to explain how estrogen influences rheumatoid arthritis, but we are not saying that it is the only one," lead researcher Phillip Kramer, PhD, tells WebMD.
Just as in rheumatoid arthritis, multiple sclerosis symptoms tend to improve during pregnancy and worsen after delivery and at menopause. But the association is reversed in lupus, which is 10 times more common among women than men. Lupus symptoms tend to worsen during pregnancy and improve when estrogen levels drop.
Boston rheumatologist and Harvard Medical School associate professor Jonathan Kay, MD, calls the new findings interesting but adds that they do not convince him that estrogen is the key player in autoimmune diseases that disproportionately afflict women. He notes that levels of the female sex hormone progesterone also rise during pregnancy and plummet at menopause.
"Plenty of women who are premenopausal with normal estrogen levels develop rheumatoid arthritis," he says. Kay cited a study from Ireland, published earlier this year, finding that estrogen replacement therapy did not appear to protect women against rheumatoid arthritis. Another study that included 158 elderly women with rheumatoid arthritis, published last fall, found the same thing.
"You would expect to see a protective effect for estrogen therapy if this association were strong," Kay says. "It may be that estrogen plays a role in rheumatoid arthritis and other autoimmune diseases, but it may not be the only sex hormone that does."
SOURCES: Kramer, P. Arthritis and Rheumatism, June 2003; vol 50: pp 1967-1975. Phillip R. Kramer, PhD, assistant professor, Baylor College of Dentistry, Texas A&M University System Health Center, Dallas. Jonathan Kay, MD, clinical director, Rheumatology Unit, Massachusetts General Hospital; associate clinical professor of medicine, Harvard Medical School.
TUTKIMUS: ESTROGEENIHORMONI - TULEHDUKSET
Valvojat: Jatta1001, Borrelioosiyhdistys, Bb
TUTKIMUS: ESTROGEENIHORMONI - TULEHDUKSET
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Lähettäjä: jukka61 Lähetetty: 23.7.2004 18:16
Sen verran tietoa on ko. hoidosta, että eräs tuttu sai ko. hoitoa Lupukseen (SLE:n), kun mikään lääkehoito ei meinannut toimia (ja kortisonista tuli sivuvaikutuksia) ja hoidon ansiosta henkilö voi paremmin, kun aikoihin. Hänenkin kohdallaan kyse oli omasta "tiedonhankinnasta" sairaudestaan ja hoitovaihtoehdoista ja lääkäri, joka tutki asian ja kokeili ennakkoluulottomasti hoitoa.
Sen verran tietoa on ko. hoidosta, että eräs tuttu sai ko. hoitoa Lupukseen (SLE:n), kun mikään lääkehoito ei meinannut toimia (ja kortisonista tuli sivuvaikutuksia) ja hoidon ansiosta henkilö voi paremmin, kun aikoihin. Hänenkin kohdallaan kyse oli omasta "tiedonhankinnasta" sairaudestaan ja hoitovaihtoehdoista ja lääkäri, joka tutki asian ja kokeili ennakkoluulottomasti hoitoa.