IgG BORRELIOOSISSA - MIELENKIINTOINEN HAVAINTO

[Bb]

Lähettäjä: Soijuv Lähetetty: 4.2.2005 11:27

Ruotsalaisessa tutkimuksessa selvitettiin borrelioosissa esiintyviä IgG alaluokkia. Aika yleisesti ajatellaan että borrelioosi olisi lähinnä ns TH1 tauti jossa sytokiiniä nimeltään interferoni gamma erittyy erityisen runsaasti. Sytokiinit säätelevät immunoglobuliinien tuotantoa. IgG alaluokilla on eri tehtävät.

Tutkimuksessa havaittiin että borrelioosia sairastavilla oli yleensä IgG1 ja IgG3 vallitsevina ja IgG 2 alhainen sekä IgG4 tuskin havaittavissa. IgG4:n puuttuminen aiheuttanee TH1 taudin kaltaisen tilanteen.

Luin hiljattain yhden suomalaisen kroonista borrelioosia sairastavan henkilön laboratoriovastauksia. Hänellä oli IgG2 alhainen vaikkakaan ei alle viitearvon, mutta IgG4 oli normaali. Borrelioosi ei siis välttämättä ole jokaisella TH1 tauti tai mahdollisesti asia ei ole selitettävissä yksinomaan IgG alaluokilla näin suoraviivaisesti.

Kuinka monelta on tutkittu IgG alaluokat eli IgG 1 - 4 ? Kirjoittakaa minulle vaikka henkilökohtaisesti osoitteeseen soijuv@hotmail.com mikäli ette halua kertoa asiasta sivuillamme.


IgG Subclasses in Lyme Borreliosis: A Study of Specific IgG Subclass Distribution in an Interferon-gamma-Predominated Disease

http://www.ingentaconnect.com/content/b ... 6/art00334

Authors: WIDHE M. 4; EKERFELT C. 4; FORSBERG P. 1; BERGSTROM S. 5; ERNERUDH J. 4

Source: Scandinavian Journal of Immunology, June 1998, vol. 47, no. 6, pp. 575-581(7)

Abstract:

Lyme borreliosis has shown a T helper type 1 (Th1)-like immune response with high production of interferon-gamma. Since the cytokine environment seems to be important in the regulation of immunoglobulin production and in the switch between different isotypes and subclasses, and since the subclasses of IgG have different functions, we wanted to examine the IgG subclass distribution in Lyme borreliosis. We have developed an ELISA measuring flagellin-specific antibodies of the different IgG subclasses in serum and cerebrospinal fluid (CSF). Thirty-five seropositive patients with varying manifestations of Lyme borreliosis were included in the study.

According to the results, the predominating subclasses in both serum and CSF were IgG1 and IgG3. In samples taken early in disease this pattern was more pronounced in patients with a subacute disease, defined as recovery within 3 months, compared to patients that later on developed chronic borreliosis. The levels of IgG2 were generally low and IgG4 was below detection level. Thus, in the IFN-gamma-predominated immune response seen in Lyme borreliosis, mainly IgG1 and IgG3 were found, i.e. the subclasses that are complement activating as well as opsonizing in humans. Increased levels of these two subclasses early in disease might contribute to recovery and counteract the development of chronicity. The absence of IgG4 is in accordance with the presumed Th1-like situation of Lyme borreliosis.

Language: English

Document Type: Research article

Affiliations: 1: Department of Health & Environment, Division of Infectious Diseases, Faculty of Health Sciences, University Hospital, Linkoping, Sweden 4: Department of Neuroscience and Locomotion, Clinical Research Centre, Faculty of Health Sciences, University Hospital, Linkoping, Sweden 5: Department of Microbiology, University of Umea, Umea, Sweden *