NEUROBORRELIOOSI/PET-KUVAUS

[Bb]

Lähettäjä: Soijuv Lähetetty: 20.9.2005 16:38

Saksalaisessa tutkimuksessa borrelioosia sairastavalla esiintyi PET-kuvauksessa sokeriaineenvaihdunnan lisääntymistä aivovarrren alueella. Amerikkalaisessa tutkimuksessa potilaalla esiintyi niinikään hypermetabolismia aivovarressa. Kummassakin tapauksessa muutoksia parempaan nähtiin seuraavassa kuvauksessa joka tehtiin antibioottihoitojen jälkeen.


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J Neurosurg. 2005 May;102(5):927-9.

Fluorine-18-labeled fluorodeoxyglucose-positron emission tomography studies of acute brainstem Lyme neuroborreliosis. Case report.

Plotkin M, Hautzel H, Krause BJ, Mohr S, Langen KJ, Muller HW.

Department of Radiology, Nuclear Medicine and Radiooncology, Campus Virchow-Klinikum, University Hospital Charite, Berlin, Germany. michail.plotkin@charite.de

The authors report on a patient suffering from acute Lyme borreliosis who underwent two consecutive [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) studies demonstrating the course of the disease. The first FDG-PET study revealed markedly increased glucose metabolism in the brainstem, matching exactly the signal abnormalities exhibited on magnetic resonance images and indicating a brainstem tumor. A second PET scan demonstrated no abnormality in this region, thus reflecting clinical remission following antibiotic therapy. Data in the present case indicate that hypermetabolic findings on FDG-PET studies in the brainstem region should be regarded with caution and that neuroborreliosis must be considered as a possible differential diagnosis.

Publication Types:
* Case Reports
PMID: 15926723 [PubMed - indexed for MEDLINE]
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Neuroradiology. 2005 Sep 13; [Epub ahead of print]

Lyme disease of the brainstem.

Kalina P, Decker A, Kornel E, Halperin JJ.

Department of Radiology, Mayo Clinic, 200 First Street, Rochester, MN, 55905, USA, kalina.peter@mayo.edu.

Lyme disease is a multisystem infectious disease caused by the tick-borne spirochete, Borrelia burgdorferi. Central nervous system (CNS) involvement typically causes local inflammation, most commonly meningitis, but rarely parenchymal brain involvement. We describe a patient who presented with clinical findings suggesting a brainstem process. Magnetic resonance imaging (MRI) and positron emission tomography (PET) suggested a brainstem neoplasm. Prior to biopsy, laboratory evaluation led to the diagnosis of Lyme disease. Clinical and imaging abnormalities improved markedly following antimicrobial therapy. We describe Lyme disease involvement of the cerebellar peduncles with hypermetabolism on PET. Although MRI is the primary imaging modality for most suspected CNS pathology, the practical applications of PET continue to expand.

PMID: 16158278 [PubMed - as supplied by publisher]