MIKROBIEN YHTEYS SYÖPIIN

[Bb]

Lähettäjä: Soijuv Lähetetty: 11.10.2005 10:52

Epidemiologisissa tutkimuksissa on todettu että noin 15 %
syöpäkuolemista on yhteydessä kroonisiin bakteeri- tai
virusinfektioihin:


Nature Reviews Immunology 5, 749-759 (2005); doi:10.1038/nri1703

NF-¦ÊB: LINKING INFLAMMATION AND IMMUNITY
TO CANCER DEVELOPMENT AND PROGRESSION

Michael Karin1 & Florian R. Greten2 about the authors

1 Laboratory of Gene Regulation and Signal Transduction, University of
California at San Diego School of Medicine, Department of Pharmacology, 9500
Gilman Drive, La Jolla, California 92093-0723, USA.
2 II Medizinische Klinik Klinikum Rechts der Isar, Techinische Universitat
M¨¹nchen, Ismaningerstrasse 22, 81675 M¨¹nchen, Germany.

correspondence to: Michael Karin karinoffice@ucsd.edu

There has been much effort recently to probe the long-recognized
relationship between the pathological processes of infection, inflammation
and cancer. For example, epidemiological studies have shown that 15% of
human deaths from cancer are associated with chronic viral or bacterial
infections. This Review focuses on the molecular mechanisms that connect
infection, inflammation and cancer, and it puts forward the hypothesis that
activation of nuclear factor-B (NF-B) by the classical, IKK-
(inhibitor-of-NF-B kinase-)-dependent pathway is a crucial mediator of
inflammation-induced tumour growth and progression, as well as an important
modulator of tumour surveillance and rejection.