BORRELIOOSIN TARTTUMINEN ÄIDISTÄ LAPSEEN

[Bb]

Lähettäjä: Soijuv Lähetetty: 14.10.2005 19:11

Kokoelma artikkeleita/tutkimuksia joissa on tutkittu borrelioosin tarttumista äidistä lapseen:


JAMA. 1986 Jun 27;255(24):3394-6. Related Articles, Links
Lyme disease during pregnancy.

Markowitz LE, Steere AC, Benach JL, Slade JD, Broome CV.

Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease.
PMID: 2423719 [PubMed - indexed for MEDLINE]


-Lyme disease can potentially adversely affect pregnancy. In 1985,researchers published the first proof of maternal-fetal transmission of Borrelia burgdorferi (Bb): A baby died shortly after birth and Bb spirochetes were found in the infant's spleen, kidney, and bone marrow.
(Schlesinger P, Duray P, Burke B, Steere A, Stillman A. Maternal-fetal transmission of the Lyme disease spirochete Borrelia burgdorferi.
Annals of Internal Med. 1985:(Vol 103) 67-68.)

To date, miscarriage, premature birth, stillbirth, neonatal deaths (rare), and congenital Lyme disease have all been described in the medical literature.

-Lyme disease and pregnancy from the CDC GUIDE TO LYME DISEASE
In rare cases, Lyme disease acquired during pregnancy may lead to infection of the fetus and possibly to stillbirth, but adverse effects to the fetus have not been conclusively documented.
http://www.nddh.org/CDC%20Guide%20to%20 ... isease.htm

-Pregnancy and Lyme Disease
http://www.geocities.com/HotSprings/Oas ... links.html

-reported an apparent transplacentally or perinatally transmitted case of Babesiosis
http://www2.us.elsevierhealth.com/scrip ... cle=a81986

- Gardner, MD, Tessa. "Lyme Disease," Chapter 11, in Infectious Diseases of the Fetus and Newborn Infant. 4th edition, Jack S. Remington,
Jerome O. Klein, eds. Philadelphia: Saunders, 1995, pp. 447-528.

-The efficacy and effectiveness of antibiotics http://www.ahrq.gov/clinic/pretermsum.htm

-Fetal outcome in murine Lyme disease
http://iai.asm.org/cgi/content/abstract/63/1/66

-Gestational Lyme borreliosis. Implications for the fetus.
MacDonald AB
Rheum Dis Clin North Am 1989 Nov 15:657-77
Abstract
Great diversity of clinical expression of signs and symptoms of gestational Lyme borreliosis parallels the diversity of prenatal syphilis. It is documented that transplacental transmission of the spirochete from mother to fetus is possible. Further research is necessary to investigate possible teratogenic effects that might occur if the spirochete reaches the fetus during the period of organogenesis. Autopsy and clinical studies have associated gestational Lyme borreliosis with various medical problems including fetal death, hydrocephalus, cardiovascular anomalies, neonatal respiratory distress, hyperbilirubinemia, intrauterine growth retardation, cortical blindness, sudden infant death syndrome, and maternal toxemia of pregnancy. Whether any or all of these associations are coincidentally or causally related remains to be clarified by further investigation. It is my expectation that the spectrum of gestational Lyme borreliosis will expand into many of the clinical domains of prenatal syphilis.

-Pregnancy and Lyme Disease
http://www.geocities.com/HotSprings/Oas ... links.html