ALS-TAUTI/BORRELIOOSI

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Lähettäjä: Soijuv Lähetetty: 25.11.2005 13:59

Australialainen sivu ALS-taudista/borrelioosista:


http://home.goulburn.net.au/~shack/lyme.htm

Lyme Disease Induced Neurodegeneration
(Neuroborreliosis)
(ALS) Amyotrophic Lateral Sclerosis or (MND) Motor Neurone Disease are referred to as ALS/MND throughout.

........
ALS AND LYME MEDICAL JOURNAL REFERENCES

1. "Borrelia burgdorferi antibodies and amyotrophic lateral sclerosis" The Lancet. August 8, 1987 Russel Johnson, MD (famous Lyme researcher in the US) et al.

Case studies are discussed whereby persons who tested positive for Lyme on antibody tests showed classic ALS symptoms including denervation, atrophy, weakness, bulbar involvement, dysarthria, ataxia and so on. The end of the article states that any person with ALS should be given the opportunity for a Lyme diagnosis based on these compelling studies.

2. "ALS-like sequelae in chronic neuroborreliosis" German newsletter entitled Wien Med Wochenschr, 1995;145(7-8 );186-8 Hansel Y, Ackerl M, Stanek G (very well known Lyme European researchers) [Lyme was very common neurologic disease in Europe in even 1800s but no one knew the organism causing it!

This study suggests that all persons diagnosed with ALS be suspect for having Lyme disease as this particular case study individual had her diagnosis changed from ALS to Lyme. She had had Lyme for many years and the long-term sequelae of the infection caused an ALS misdiagnosis.

3. "Neurologic Complications of Lyme Disease" Rheumatic Dis Clinical North America, 1993 Nov;19(4):993-1009 Coyle, Patricia K. (Neurologist at Stony Brook University, New York).

Quote from the article: "Lyme disease should be included in the differential diagnosis [editors note: by physicians] of most major neurologic syndromes."

4. "Clinical and electrophyphsiologic findings in chronic neuropathy of Lyme Disease" Logigian El et al., Neurology 1992 Feb, 42(2):303-11. 48% had distal neuropathy involvement with multifocal losses. Weakness, hyporeflexia were present in some and motor or sensory nerve conduction showed slowing in 64%. 48% had radicular (nerve root pains). 75-80% of patients , with needle EMG studies showed DENERVATION IN PARASPINAL AND LIMB MUSCLES. 76% of patients showed improvement with intravenous rocephin therapy

5. Immunologic Reactivity Against Borrelia burgdorferi in Patient with Motor Neuron Disease" Archives of Neurology-Vol 47, May1990, p. 586-594. Author: John J. Halperin, MD et al. (one of President Bush's doctors and many other [et al].

Abstract: The findings of this study are the most powerful of all studies done to date. A group of Suffolk New York "CLASSIC ALS" patients were taken for the study. They were not classic Lyme patients. All were given antibiotic. Some did not do anything, some did very well and the bulbar group deteriorated rapidly. (Remember, the reason for this Deterioration was hypothetically due to a very common research problem Back then... the length and type of treatment given to the severe bulbar group was probably not only long enough but the rapid deterioration was a definite sign of the Lyme infection because of the Jarisch-Herxheimer Reaction. This reaction only occurs with infections like lyme and the Only way a group could either not respond or do a rapid decline on Treatment would be due to this endotoxin released by the spirochete Bacteria when antibiotics kill it. The endotoxin given off by the Spirochete causes an immunologic reaction which is very difficult for all Lyme patients but passes with time. No doubt the bulbar group received A short duration of therapy and no one was aware of this reaction and Their need for individualized therapy... even oral perhaps as opposed to IV or perhaps pulse therapy whereby the patient takes IVs only a few days a week as opposed to daily to try and minimize this reaction).

Similarly, those who did not respond, were probably like me. It took me 16 weeks of intravenous antibiotic to get well my first treatment! I am sure these research patients were given only 2-4 weeks of IV. [After 2-4 weeks of IV, I was so sick from the cyclical immunologic exacerbation of symptoms of the JH reaction that I could barely stand to be in my body from all the strange neurologic things going on. I felt better in some ways but much worse in others and it took me 16 weeks straight on IVs to get well!

One case of a 35 yo male who was paralyzed from Lyme and on a ventilator, required a full year of IV claforan to bring him back to living alone and fully-functioning again, able to drive etc. He had severe brain-stem demyelination and encephalitis and was very, very acutely ill. Heis fine now other than the damage from the dysarthria. He sounds as if he has had a stroke.

The results of this study were profound: There was a statistically significant reversal of neurologic function of classic ALS patients taking antibiotic for Lyme in this study!

If I were an ALS patient, this study alone would make me run for antibiotics treatment. Now the Lyme specialists no longer use a short 4-6 week course of antibiotics but rather they individualize your length of therapy depending on the time it takes you to get better.

6. "Neuroborreliosis as a cause of respiratory failure", Journal of Neurology, 242:9, 1995 Sep.604-7. Silva MT, et al. LaneFox Respiratory Unit, St. Thomas' Hospital, London, UK.

Three cases of Lyme causing acute respiratory impairment requiring ventilatory support. TWO OF THE THREE HAD BRAINSTEM INVOLVEMENT. All of these patients ALSO had central apnoea requiring tracheostomy, etc.

7. "Chronic Neurologic Manifestations of Lyme Disease" Logigian et al. New England Journal of Medicine, Nov. 1990.

Neurologic studies and neuropsychiatric studies were performed on a group of Lyme patients. Findings showed that a group of Lyme patients had both proximal and distal paraspinal denervation on electromyographic testing (EMG) with clearly ALS signs. EMG studies revealed neuropathy both proximal and distal with noted denervation, atrophy and weakness.

8. "Pathogenesis of immune-mediated neuropathies" [Immune-meidated is a = way of avoiding the use of "autoimmune" meaning that something has "triggered" the immunologic damage of the nervous system such as the spirochete infection.]

Pediatr Res, 1993 Jan,33(1Suppl):S90-4 Dept. Neurology, University Pennsylvania School of Medicine
In this abstract, Guillain-Barre disease is the topic with Lyme mentioned as well. NERVE CONDUCTION VELOCITY SLOWING AND SEGMENTAL DEMYELINATION IS MENTIONED. Many patients with Lyme disease have had a hard hit to their immune systems by this immune-suppressing infection and many of us have had to have gammaglobulin intravenously to help us fight the infection. This study mentioned the use of gammaglobulin therapy IV for GB patients as well.

9. "Detection of Borrelia burgdorferi DNA and complement menbrane attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease." Institute of Neurological Sciences, University of Siena, Italy. Muscle Nerve, 1997 Aug;20(8 ):969-75. Maimone D, Villanova M, et al.

This study delves into polyneuropathies, sural nerve biopsy showing spirochete infection, EMG findings etc.

10. Lyme Borreliosis neuropathy. A case report." American Journal of Physician Medicine and Rehabilitation, 1996 Jul;75(4):314-316.
This study is significant for ALS in that "electro physiologic studies demonstrate a PROXIMAL AND DISTAL AXONAL INVOLVEMENT." It even suggests that EMGs may show improvement in clinical changes as therapy begins to improve neurologic involvement. This report suggests that some peripheral neuro involvements may resolve while other neuro symptoms may not. Responses vary.

11. "Myositis during Borrelia burgdorferi infection (Lyme Disease) Schoenen J., et al, Journal Neurology and Neurosurgical Psychiatry 1989, Aug;52(8 ):1002-5.

Patient developed myopathic syndrome with severe muscular pains, incapacitating weakness of the proximal limb and the neck, as well as the bulbar muscles. Steroids stopped symptoms for a while but only antibiotics improved the paresis.

12. "Central nervous system manifestations of Lyme disease. Pachner AR, Duray P, et al. Achives of Neurology, 1989 July;46(7):790-5
Weeks to years after this infection, behavioral changes, ataxia, and/or WEAKNESS IN BULBAR OR PERIPHERAL MUSCLES DEVELOPED." All 6 patients in this study were treated with IV penicillin high dose but the length was not mentioned. Four had response and 2 did not... again perhaps due to length of therapy not being long enough?

13. "Multiple Neurologic manifestations of Borrelia burgdorferi infection" [article in French] Author-dupuis, MJ, Revue of Neurology (Paris) 1988;144(12):765-775. Clinique St.-Pierre, Ottignies, Belgique.

"The neurologic spectrum of Borrelia burgdorferi is still enlarging. The following neuro manifestations are mentioned: meningitis, acute or relapsing neuro symptoms such as palsies, cranial neuropathies, peripheral nerve involvement, acute transverse myelitis and paralysis, encephalitis, myositis, chronic neuropathy, sensory and MOTOR IMPAIRMENT AND SIGNS, recurrent stroke, progressive neuro disease, optic atrophy, DYSARTHRIA, SLOWLY OR PROGRESSIVE ATAXIA, SPASTIC GAIT DISORDER, ABNORMAL EMGs, Etc.

Lyme Neuroborreliosis (NB) is often thought to be mistaken for... (Neurological illnesses) http://www.actionlyme.com/Multiple_Sclerosis.htm

NB is is also thought to be a form of (MS). And NB is often thought to be the initiating cause of chronic neurological disease, without the infection being present. There seems to be little difference clincally, and the statistic is 25% of MS cases are cases exposed to Borrelia burgdorferi (Coyle). But if the testing was better, it might reveal a greater linkage. Approximately the same number is ~47% in endemic areas, that Borrelia burgdorferi exposure is associated with Amyotrophic Lateral Sclerosis (Dattyler, Halperin). Even the markers are similar, in the the indices of these three diagnoses. Two clinical trials are underway that suggest an association of ALS or MS to borreliosis.

Antibiotics and ALS: NIH CLINICAL TRIALS:
http://www.clinicaltrials.gov/ct/gui/sh ... 23?order=2

ALS and Borreliosis: http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

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Lähettäjä: Soijuv Lähetetty: 2.12.2005 8:16

Jatkoa ALS/borrelioosi aiheeseen. Tämän viikon Avussa (nro 47) suomalainen ALS-oireisiin sairastunut nainen sai vuoden elinaikaa. Hän päätti kokeilla kantasoluhoitoa Neurovita-klinikalla Moskovassa. Lääkärin mukan 3 - 6 kk kuluttua on odotettavissa radikaaleja parannuksia.