Lähettäjä: Soijuv Lähetetty: 22.12.2005 18:16
Ensimmäinen havainto Borrelia burdorferi -bakteerin resistenssistä fluoroquinoloni-antibiooteille:
Antimicrobial Agents and Chemotherapy, October 2005, p. 4354-4357, Vol. 49, No. 10
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.10.4354-4357.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi
Kendal M. Galbraith,{dagger} Amanda C. Ng, Betsy J. Eggers, Craig R. Kuchel, Christian H. Eggers,§ and D. Scott Samuels*
Division of Biological Sciences, The University of Montana, Missoula, Montana 59812
Received 26 May 2005/ Returned for modification 29 June 2005/ Accepted 29 July 2005
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
* Corresponding author. Mailing address: Division of Biological Sciences, The University of Montana, 32 Campus Dr. 4824, Missoula, MT 59812-4824. Phone: (406) 243-6145. Fax: (406) 243-4304. E-mail: scott.samuels@umontana.edu .
Present address: Department of Medical Microbiology & Immunology, University of Wisconsin, Madison, WI 53706.
Present address: Department of Virology, Bristol-Myers Squibb Company, Wallingford, CT 06492.
§ Present address: Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington
BB/FLUOROQUINOLONI-ANTIBIOOTIT
Valvojat: Jatta1001, Borrelioosiyhdistys, Bb