Lähettäjä: Soijuv Lähetetty: 15.1.2006 15:59
Leptiinihormonin estolla suotuisia vaikutuksia autoimmuuniperäisissä aivotulehduksisa esim. MS-taudissa:
http://www.medicalnewstoday.com/medical ... wsid=36108
Blocking Leptin Helps Halt And Heal Multiple Sclerosis
13 Jan 2006
Italian researchers have found that blockade of the hormone leptin, which is primarily produced in fats cells, has beneficial effects on the induction and progression of experimental autoimmune encephalomyelitis (EAE) in mice - the animal model of human multiple sclerosis (MS). In their study appearing online on January 12 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation, Giuseppe Matarese and colleagues from Università di Napoli "Federico II" suggest that leptin neutralization may be a potential way to both prevent and treat MS.
MS is an inflammatory disease of the brain and spinal chord characterized by muscle weakness, numbness, and loss of coordination. These symptoms result in part from destruction of the nerve-insulating material myelin by activated T cells.
Leptin is known to play a critical role in the regulation of food intake, metabolism, and the immune response. Since it had been previously shown that leptin is expressed in active inflammatory lesions of the central nervous system during EAE and MS, Matarese and colleagues investigated the effects of leptin blockade on the induction and progression of EAE in mice. They found that leptin blockade by the use of either anti-leptin antibodies or a form of the leptin receptor unable to bind leptin, either before or after disease onset improved clinical symptoms of disease, slowed disease progression, reduced disease relapses, and reduced the number of antigen-specific T cells. The authors delved further to unravel the cellular signaling events underlying these beneficial effects. Taken together, the data provide a basis for the development and testing of novel strategies of leptin-based targeting for the potential treatment of MS.
TITLE: Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
AUTHOR:
Giuseppe Matarese
Università di Napoli "Federico II", Napoli, Italy.
View the PDF of this article at:
the-jci.org/article.php?id=26523
Brooke Grindlinger
press_releases@the-jci.org
Journal of Clinical Investigation
www.jci.org
© 2003-2006 Medical News Today
LEPTIINI AUTOIMMUUNITULEHDUKSISSA
Valvojat: Jatta1001, Borrelioosiyhdistys, Bb
LEPTIINI AUTOIMMUUNITULEHDUKSISSA
Viimeksi muokannut Bb, La Maalis 07, 2009 15:27. Yhteensä muokattu 2 kertaa.
Lähettäjä: Soijuv Lähetetty: 24.1.2006 10:52
Leptiini on uuden tutkimuksen mukaan tehokasta myös masennuksen hoidossa:
Leptin 'a potential novel antidepressant' 18 January 2006 Proc Natl Acad Sci 2006; Early online publication Investigators have found additional evidence for a role of leptin in mood and emotion, suggesting the hormone may prove to be an effective treatment for depression in some individuals. Leptin, which is secreted from adipose tissue, is normally associated with the regulation of body weight, but localization of the leptin receptor in limbic structures has led to the suggestion of a potential role for the hormone in emotional processes. To investigate this potential role of leptin further, researchers from the University of Texas Health Science Center in San Antonio, USA, examined circulating leptin levels in rats exposed to chronic unpredictable stress and chronic social defeat, as these stress paradigms produce behavioral deficits that resemble some aspects of human depression. Rats subjected to such stress had significantly lower plasma levels of leptin, with concurrent elevations in corticosterone levels, compared with non-stressed animals. Similar reductions in leptin levels were seen in the socially defeated rats when compared with handled controls, but corticosterone levels did not differ significantly between the two groups. The antidepressant effect of leptin was then evaluated using behavioral alterations caused by chronic stress and the forced swim test. One of the depression-like phenotypes induced by chronic stress is decreased sucrose preference, which the researchers note was reversed by acute administration of leptin. Sucrose preference in non-stressed rats was not affected by leptin treatment. In the forced swim test, rats show 'despair' behavior, including immobility and escape-oriented behavior. Administration of leptin during this test, however, produced a dose-dependent reduction in the duration of immobility and increased the duration of swimming time. Moreover, examination of messenger (m)RNA expression of c-fos, a neuronal activation marker, indicated that leptin's action in rats undergoing the forced swim test was linked to activity in specific limbic structures. "In particular, the robust increase in c-fos expression in the hippocampus in response to leptin treatment suggests that this brain area might be a target site of circulating leptin for its antidepressant-like actions, the team writes in the Proceedings of the National Academy of Sciences. They conclude: "Elevating leptin signaling in [the] brain may represent a novel approach for the treatment of depressive disorders."
Leptiini on uuden tutkimuksen mukaan tehokasta myös masennuksen hoidossa:
Leptin 'a potential novel antidepressant' 18 January 2006 Proc Natl Acad Sci 2006; Early online publication Investigators have found additional evidence for a role of leptin in mood and emotion, suggesting the hormone may prove to be an effective treatment for depression in some individuals. Leptin, which is secreted from adipose tissue, is normally associated with the regulation of body weight, but localization of the leptin receptor in limbic structures has led to the suggestion of a potential role for the hormone in emotional processes. To investigate this potential role of leptin further, researchers from the University of Texas Health Science Center in San Antonio, USA, examined circulating leptin levels in rats exposed to chronic unpredictable stress and chronic social defeat, as these stress paradigms produce behavioral deficits that resemble some aspects of human depression. Rats subjected to such stress had significantly lower plasma levels of leptin, with concurrent elevations in corticosterone levels, compared with non-stressed animals. Similar reductions in leptin levels were seen in the socially defeated rats when compared with handled controls, but corticosterone levels did not differ significantly between the two groups. The antidepressant effect of leptin was then evaluated using behavioral alterations caused by chronic stress and the forced swim test. One of the depression-like phenotypes induced by chronic stress is decreased sucrose preference, which the researchers note was reversed by acute administration of leptin. Sucrose preference in non-stressed rats was not affected by leptin treatment. In the forced swim test, rats show 'despair' behavior, including immobility and escape-oriented behavior. Administration of leptin during this test, however, produced a dose-dependent reduction in the duration of immobility and increased the duration of swimming time. Moreover, examination of messenger (m)RNA expression of c-fos, a neuronal activation marker, indicated that leptin's action in rats undergoing the forced swim test was linked to activity in specific limbic structures. "In particular, the robust increase in c-fos expression in the hippocampus in response to leptin treatment suggests that this brain area might be a target site of circulating leptin for its antidepressant-like actions, the team writes in the Proceedings of the National Academy of Sciences. They conclude: "Elevating leptin signaling in [the] brain may represent a novel approach for the treatment of depressive disorders."