VIRTSATEIDEN TULEHDUS/BB

[Bb]

Lähettäjä: Soijuv Lähetetty: 7.3.2006 9:43

Useilla borrelioosia sairastavilla esiintyy aika ajoin tai kroonisesti virtsateiden tulehduksia. Tutkimuksissa on todettu borreliabakteerien suosivan mm. virtsarakkoa ja aiheuttavan virtsarakon tulehduksia.


Am J Pathol. 1992 Nov;141(5):1173-9.
Cystitis induced by infection with the Lyme disease spirochete, Borrelia burgdorferi, in mice.

Czub S, Duray PH, Thomas RE, Schwan TG.

Department of Health and Human Services, National Institutes of Health,
National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840.

Previous studies have demonstrated that the urinary bladder is a consistent
source for isolating the Lyme disease spirochete, Borrelia burgdorferi, from
both experimentally infected and naturally exposed rodents. We examined
histopathologic changes in the urinary bladder of different types of rodents
experimentally infected with Lyme spirochetes, including BALB/c mice (Mus
musculus), nude mice (M. musculus), white-footed mice (Peromyscus leucopus),
and grasshopper mice (Onychomys leucogaster). Animals were inoculated
intraperitoneally, subcutaneously, or intranasally with low-passaged
spirochetes, high-passaged spirochetes, or phosphate-buffered saline. At
various times after inoculation, animals were killed and approximately
one-half of each urinary bladder and kidney were cultured separately in
BSK-II medium while the other half of each organ was prepared for histologic
examination. Spirochetes were cultured from the urinary bladder of all 35
mice inoculated with low-passaged spirochetes while we were unable to
isolate spirochetes from any kidneys of the same mice. The pathologic
changes observed most frequently in the urinary bladder of the infected mice
were the presence of lymphoid aggregates, vascular changes, including an
increase in the number of vessels and thickening of the vessel walls, and
perivascular infiltrates. Our results demonstrate that nearly all
individuals (93%) of the four types of mice examined had a cystitis
associated with spirochetal infection.

PMID: 1443051 [PubMed - indexed for MEDLINE]