PSYYKKISET SAIRAUDET MIKROBIEN AIHEUTTAMIA?

[Bb]

Lähettäjä: Soijuv Lähetetty: 25.6.2006 20:45

Skitsofreniaa ja kaksisuuntaista mielialahäiriötä sairastavat saattavat tosiasiassa sairastaa mikrobien esim. eri herpesvirusten aiheuttamaa aivotulehdusta. Potilaiden hoito antibiooteilla ja viruslääkkeillä on osoittautunut lupaavaksi varsinkin taudin alkuvaiheessa.

Mikrobien osuus näihin sairauksiin on ollut esillä jo vuodesta 1896 !! (Suom. huom. voi vain ihmetellä mihin asiaa koskeva tutkimus on haudattu yli sadaksi vuodeksi. Eikä liioin ihme etteivät tutkimustulokset tahdo saada jalansijaa hoitokäytäntöihin.)

Koko artikkeli: http://www.psychiatrictimes.com/article ... 142&pgno=2


Infectious Agents in Schizophrenia and Bipolar Disorder

By Robert H. Yolken, MD and E. Fuller Torrey, MD

Page 1 of 2

edited by Stanley N. Caroff, MD

June 2006, Vol. XXIII, No. 7

The idea that schizophrenia and bipolar disorder might be caused by infection is not new. This was a prominent hypothesis in the early years of the last century. For example, an article entitled, ?Is insanity due to a microbe?? was published in Scientific American as early as 1896. Research to test this hypothesis by identifying causative viruses was already being conducted by the 1930s, when data were reported from experiments in which cerebrospinal fluid (CSF) from patients with schizophrenia was injected into rabbit brains.1

New research in the field continues, aided increasingly by impressive technologic advances in microbiology and virology. As recently as the past decade, reports documented the presence of influenza virus, rubella virus, bovine disease virus, and other infectious agents in patients with schizophrenia and bipolar disorder, as well as the presence of other infectious agents in childhood pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) and obsessive-compulsive disorder.

In this article, we briefly highlight the background of such research; discuss our own research on Toxoplasma gondii, herpes simplex virus (HSV), Cytomegalovirus (CMV), and endogenous retroviruses; and consider the future implications of such research for psychiatric clinicians.
...Implications for clinicians

Proving a causative role for infectious agents in schizophrenia and bipolar disorder would open the door to new treatments and disease prevention strategies. With the support of The Stanley Medical Research Institute, we are conducting several double-blind treatment trials that involve the use of adjunctive antibiotics and antiviral medications in persons with schizophrenia and bipolar illness. To date, these medications show some promise in patients with recent-onset disease. The results are less remarkable in persons with long-standing illness. In the future, it might even be possible to develop a vaccine to protect children against possible infections that contribute to these 2 mental illnesses.

Even with what is known today, in clinical settings, some patients who present initially with symptoms suggestive of schizophrenia or bipolar disorder could instead be in the initial stages of viral encephalitis. Some physicians would argue that patients with first-admission psychosis should have a lumbar puncture and CSF analysis, adding other studies as appropriate if indicated by an increase in CSF protein or lymphocytes. A small sample of the CSF could be frozen and stored for future analysis. With further advances in research at the interface between psychiatry and infectious disease, these samples may eventually provide the key to proving the connection between infection and mental disturbance, and pave the way for pharmacologic treatment specifically targeted to that causative infectious organism.