MIELENKIINTOINEN TUTKIMUS

[Bb]

Lähettäjä: Soijuv Lähetetty: 31.3.2004 9:02

Mielenkiintoinen tutkimus; borreliavasta-aineita voidaan lisätä estämällä gamma interferonin (IFN-gamma) vaikutusta.

Gamma interferon neutralization of augments severe Lyme arthritis.

Drug Week, March 26, 2004 p314.

Full Text COPYRIGHT 2004 NewsRX

According to published research from the United States, "Development of a high level of sustained borreliacidal antibody is paramount for maintaining protection against infection with Borrelia burgdorferi. We show that production of borreliacidal antibody can be enhanced by preventing the effects of gamma interferon (IFN-gamma). When lymph node cells capable of producing borreliacidal antibody were cultured with anti-murine IFN-gamma, an eight-fold increase in borreliacidal antibody production was obtained."

"However, anti-IFN-gamma treatment of these cells also enhanced their ability to adaptively induce arthritis," said Erik L. Munson and "When anti-IFN-gamma-treated lymph node cells producing borreliacidal antibody were infused into C3H/HeJ mice and the mice were then challenged with B. burgdorferi, the mice developed severe destructive Lyme arthritis. Additional studies are needed to delineate the immune response responsible for the induction of arthritis and production of borreliacidal antibody. These studies are needed to ensure an effective and safe vaccine against infection with B. burgdorferi."

Munson and his collaborators published their findings in Clinical and Diagnostic Laboratory Immunology (Neutralization of gamma interferon augments borreliacidal antibody production and severe destructive Lyme arthritis in C3H/HeJ mice. Clin Diagn Lab Immunol, 2004;11(1):35-41).

Additional information can be obtained by contacting Ronald F. Schell, Wisconsin State Laboratory of Hygiene, University of Wisconsin, 465 H Mall, Madison, WI 53706, USA. E-mail: RFschell@facstaff.wisc.edu.

The publisher of the journal Clinical and Diagnostic Laboratory Immunology can be contacted at: American Society for Microbiology, 1752 N Street NW, Washington, DC 20036-2904, USA.

The information in this article comes under the major subject areas of Lyme Disease, Tick-Borne Disease, Bacteriology, Immunology, and Proteomics.

This article was prepared by Drug Week editors from staff and other reports.
Copyright 2004, Drug Week via NewsRx.com & NewsRx.net