BORRELIOOSIN AIHEUTTAMIA AIVOMUUTOKSIA

[Bb]

Lähettäjä: Soijuv Lähetetty: 21.9.2005 8:41

Tutkimuksessa esitellään 3:n neuroborrelioosiin
kuolleen henkilön tapaus. Henkilöillä oli mm.
muutoksia aivojen valkeassa aineessa, sienimäistä
muodostusta, turvotusta, atrofiaa jne.


Folia Neuropathol. 1999;37(1):43-51.
Central nervous system infection caused by Borrelia burgdorferi.
Clinico-pathological correlation of three post-mortem cases.

Bertrand E ,Szpak GM ,Pilkowska E ,Habib N ,Lipczynska-Lojkowska W ,Rudnicka
A ,Tylewska-Wierzbanowska S ,Kulczycki J .

Department of Neuropathology, Institute of Psychiatry and Neurology,
Warszawa.

The spirochete Borrelia burgdorferi (B. burgdorferi) may cause severe
meningoencephalomyelitis as the sole manifestation of Lyme borreliosis. We
would like to present three such cases, where definite neuroborreliosis was
clinically diagnosed in two cases and possible neuroborreliosis was
recognized in one case. Alive spirochetes were isolated and cultured from
blood and cerebrospinal fluid (CSF) in both definite cases. B. burgdorferi
as the causative agent of the infection was confirmed in CSF by polymerase
chain reaction (PCR) in one definite case. In the possible case spirochetes
were cultured from blood and CSF. Alive spirochetes were not isolated,
however anti-B. burgdorferi antibody value in serum was significantly
elevated. On necropsy gross examination brain edema without focal changes
was detected in two cases. Cerebral atrophy was seen in Case 3.
Microscopically, lymphocytic infiltrates, microglial diffuse and nodular
activation, spongiform changes, diffuse demyelination of the cerebral and
cerebellar white matter, and diffuse astrocytosis, were characteristic
pathological features in all presented cases. Multifocal, perivascular
degenerative changes in the cerebral and cerebellar white matter were
observed in the first case. Inflammatory changes in the nuclei and roots of
cranial nerves were present in the third case.

Publication Types:
Case Reports

PMID: 10337063 [PubMed - indexed for MEDLINE]