INTERFERONI KESKUSHERMOSTOSAIRAUKSIEN HOIDOSSA

[Bb]

Lähettäjä: Soijuv Lähetetty: 13.11.2005 9:43

Interferonia käytetään mm. infektiotaudeissa ja autoimmuunisairauksissa. Interferonien on huomattu toimivan mm. viruksia vastaan. IFN:t säätelevät todennäköisesti keskushermoston, immuunijärjestelmän ja endokriinisen järjestelmän välistä toimintaa.


European Journal of Pharmacology
Volume 523, Issues 1-3 , 31 October 2005, Pages 1-15

doi:10.1016/j.ejphar.2005.08.029
Copyright © 2005 Elsevier B.V. All rights reserved.
Review article

Interferon and the central nervous system

Nachum DafnyCorresponding Author Contact Information, E-mail The Corresponding Authorand Pamela B. Yang

Department of Neurobiology and Anatomy, The University of Texas, Medical School at Houston, P.O. Box 20708, Houston, Texas 77225, USA
The University of Texas, Graduate School of Biomedical Sciences, P.O. Box 20708, Houston, Texas 77225, USA

Received 20 January 2005; revised 1 July 2005; accepted 18 August 2005. Available online 14 October 2005.
Abstract

Interferons (IFNs) were discovered as natural antiviral substances produced during viral infection and were initially characterized for their ability to ?interfere? with viral replication, slow cell proliferation, and profound alteration of immunity. The IFNs are synthesized and secreted by monocytes, macrophages, T-lymphocytes, neurons, and glia cells. The different IFNs are classified into three classes: alpha, beta, and gamma. á-IFN produced in the brain exerts direct effects on the brain and endocrine system by activating the neurosecretory hypothalamic neurons and regulates the hypothalamic?pituitary?adrenocortical axis. IFNs modulate neurophysiological activities of many brain region involving in pain, temperature, and food intake regulation. á-IFN administration activates the sympathetic nerves innervating components of the immune system. IFNs may serve as regulatory mediators between the central nervous system, the immune system, and endocrine system. IFN is used as immunologic therapy to treat various hematologic malignancies and infectious ailments and autoimmune diseases.

Keywords: Interferon alpha; Beta; Gamma; Immune; Endocrine; Sleep; Food; Temperature; Glucose sensitive; Opiate; Naloxone

Corresponding Author Contact InformationCorresponding author. Tel.: +1 713 500 5616; fax: +1 713 500 2515.

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