UUSI BORRELIATESTI

[Bb]

Lähettäjä: Soijuv Lähetetty: 20.4.2006 13:51

Italialaiset ovat kehittäneet uudenlaisen vasta-ainetestin varhaisvaiheen borrelioosin hoidon tuloksellisuuden toteamiseksi. Tutkimukseen osallistui 67 henkilöä joilla oli borreliabakteerin aiheuttama ihomuutos. Kaikki saivat antibioottia ja olivat 3 - 6 kuukauden seuranta-ajan kuluessa oireettomia. 15 henkilöä oli alussa IgG positiivisia, mutta 2 - 6 kk:n kuluttua negatiivisia.

Tutkijoiden mukaan Anti-VlsE vasta-ainetason lasku on merkkinä tuloksellisesta hoidosta. (Suom. huom. Borreliabakteerin kyky piiloutua on tunnettu tosiasia. Siksi edellämainittu johtopäätös on ennenaikainen. Henkilöiden tilaa tulisi seurata vuosien ajan luotettavamman kuvan saamiseksi.)


http://www.ncbi.nlm.nih.gov/entrez/quer ... &DB=pubmed

Clin Vaccine Immunol. 2006 Apr;13(4):525-9.

A Decrease in the Immunoglobulin G Antibody Response against the VlsE Protein of Borrelia burgdorferi Sensu Lato Correlates with the Resolution of Clinical Signs in Antibiotic-Treated Patients with Early Lyme Disease.

Marangoni A, Sambri V, Accardo S, Cavrini F, Mondardini V, Moroni A, Storni E, Cevenini R.

Section of Microbiology, DMCSS, University of Bologna, St. Orsola Hospital, via Massarenti 9, Bologna 40138, Italy. vsambri@med.unibo.it.

The purpose of this study was to evaluate the diagnostic performance of the LIAISON Borrelia Screen (Diasorin, Saluggia, Italy), a new automated immunoassay based on the chemiluminescent technology (chemiluminescence immunoassay). To assess whether a decrease in a negative value in the anti-VlsE immunoglobulin G (IgG) antibody titer was correlated with a positive response to treatment, a group of serially collected serum samples from 67 patients with culture-confirmed erythema migrans was retrospectively studied. All the patients had been treated with antibiotics and were free of disease within 3 to 6 months of follow-up. All the 15 patients who were found to be IgG positive at the time of enrollment and who were bled at least four times during the follow-up became IgG seronegative at 2 to 6 months posttreatment. These results indicate that a decline in the anti-VlsE antibody titer coincides with effective antimicrobial therapy in patients with early localized Lyme disease.
PMID: 16603623 [PubMed - in process]