BORRELIOOSIN HOIDOSTA JA TUTKIMUKSISTA

[Bb]

Lähettäjä: Soijuv Lähetetty: 26.3.2004 18:59

Mielenkiintoinen artikkeli borrelioosin hoidosta ja tutkimuksista:

The Mattman Study
Jo Anne Whitaker, M.D.,? Eleanor G. Fort, B.G., M.T.? Minter H. Dopson,? Lida H. Mattman, Ph.D.,?Sally M. Marlowe,N.P."
?Bowen Research and Training, Tarpon Springs, FL, USA, ? Chisolm Biological Laboratory, Aiken, SC, USA ? Nelson Medical Research, Warren, MI, USA (4) Arthritis Pain Treatment Center, Clearwater, FL, USA

INTRODUCTION
Health is a state of balance. Because humans and microbes are often competitors, interactive co-evolution has resulted in multiple and varied defense mechanisms on the part of both. The body must juggle and perform delicate balancing acts to maintain adaptive successes in spite of constantly changing life situations.

Lyme Disease (LD), Fibromyalgia (FMS), Chronic Fatigue Syndrome (CFS), Gulf War Syndrome (CWS), and many similar chronic conditions affect multiple body systems often accompanied by extreme morbidity.

Laboratory diagnostic methods presently in use are often undependable. We believe The Gold Standard Culture method developed by Lida Mattman, Ph.D. is the only consistently dependable procedure for the demonstration of the spirochete, Borrelia burgdorferi (Bb), the causative agent of LD. It is becoming increasingly obvious that the plethora of multiple clinical signs and symptoms associated with LD are also common to patients with FMS, CFS, GWS, and other commonly referred to as immune diseases.

Most physicians do not consider LD to be a cause of these syndromes, thus, allowing untold numbers of direly ill patients to suffer without the antibiotic treatments which will improve their clinical situation, and, in some cases, cure their disease (acute LD).


MATERIALS AND METHODS
(1) The Mattman Blood Culture Technique for identification of BB was used. Her success in producing positive cultures involved initiating growth in cell-wall deficient forms of the spirochete.
(2) LUAT (Lyme Urine Antigen Test) performed at Igenex.
(3) Peripheral Blood Smears with Giemsa Stain (4) Live cell analysis.

Results
103 subjects exhibiting clinical evidence of multiple body system involvement were studied. The Mattman Blood Culture was positive for Bb in 94 subjects. 37 subjects were tested by LUAT for Bb antigen and 19 of the 37 tested positive.

Smears were done on blood taken from the subjects. There was evidence of bone marrow stimulation characterized by hypochromia, red blood cells (RBCs) inclusions (stippling or parasites) and large polychromatic RBCs Platelets and white blood cells appeared normal.

Extreme fragility of RBCs was detected in many (nonspherocytic). Live Cell Analysis was also performed on the blood of the subjects and followed over 4 days ( same preparation).

Upon standing, most striking was parasitization of RBCs by ring forms, and in many cases spirochetes emerging from RBCs.

There existed extreme degradation of red blood cell membranes.

Cystic and large L-Body forms were frequent.


Breakdown of diagnosis and the number of subjects:
Fibromyalgia - 30
Osteoarthritis - 1
Mixed Connective Tissue Disease - 3
Polymyalgia Rheumatica - 1
Ankylosing Spondylitis - 1
Lupus Erythematosus - 1
Palindromic Rheumatism - 1
Chronic Fatigue Syndrome - 8
Multiple Sclerosis - 40
Amyotrophic lateral Sclerosis - 17

DISCUSSION
When Fleming discovered the miracle drug, penicillin by mistake, he observed that it worked by altering the cell wall, thus, preventing replication.

The Mattman Culture Method induces positive growth by supporting the cell-wall deficient forms. These forms are extremely stealthy in their proclivity for pleomorphism, suggesting other genera.

The ambiance of their surrounding medium is probably responsible for these changes and migration to all part of the body in the interest of self-preservation. Without intact cell walls their receptors are disadvantaged.

It is essential that the "medical world" question the validity of present laboratory methods in detecting Bb and recognizes that Lyme disease, sometimes a killer but almost always a disabler, is a disease just as fearsome as "The Great Imitator", syphilis, and about to become just as widespread.

Success in treating LD can best be achieved with early clinical diagnosis and the initiation of proper long-term antibiotic and antigen-specific Transfer Factor therapies. Until this is achieved, there will continue to be great cost not only to patients progressing to chronic neuroborreliosis, but also to the public health community.

One of the most crucial diagnostic tools, the initiation of a trial antibiotic regimen and antigen-specific Transfer Factor therapies, and the resulting Herxheimer reaction (belived by may "Lyme Savvy" practitioners to be the best indicator of LD response) must be embraced and practiced.

It is paramount to accept the fact that Lyme disease is the most common and rampant vector- borne infectious disease in the US.