KROONINEN BORRELIOOSI/HOITO

[Bb]

Lähettäjä: Soijuv Lähetetty: 29.3.2004 15:25

Tutkimukseen osallistui 962 potilasta joista suurin osa sairasti kroonista borrelioosia. Vain 13 %:lla vasta-aineet olivat koholla (ELISA, WB). Onnistuneen ab-hoidon jälkeen 54 %:lla sairaus uusiutui (seuranta-aika 2 v.). Uusi hoitojakso auttoi 85 % potilaista. Miettimään jää, miten potilaat ovat selvinneet tähän päivään saakka eli kuinka monella oireet ovat jälleen uusineet. Kuten tiedämme, oireet voivat pysyä poissa vuosikausiakin.


http://www.lyme.org/conferences/99_abstract.html

Monitoring Lyme Disease in the Community - First Sentinel Health Site
Daniel Cameron, M.D., M.P.H.

Hypothesis: New and innovative designs are necessary if we are ever to improve the understanding of chronic Lyme disease.

Design: This sentinel health site is set in a private medical practice in Mt. Kisco,Westchester County, New York, USA, an area hyperendemic for Lyme disease. This sentinel health site evaluated a consecutive case series cohort (n=1181) and followed the cohort prospectively. 962 patients were evaluated and treated for Lyme disease from June 1997 to February 1999. 219 patients (19%) were evaluated, observed, but not treated, thus not included in this analysis.

Results:

1) The majority of the 962 treated patients (83%) presented with chronic Lyme disease,the remaining 17% with an erythema migrans rash.

2) Only 123 patients (13%) presented with a positive ELISA with Western Blot confirmation.

3) The treatment success for an initial presentation of chronic Lyme disease was 80%.

4) The prevalence of relapses was 54%.

5) The one year incidence of a relapse was 19%.

6) The success rate of retreating the first relapse was 85%.

Conclusions:

This sentinel health site easily affords a timely response to current research questions. When examined using a sentinel health site a high proportion of chronic Lyme disease is revealed, most not able to be confirmed with a positive Western Blot.

Most Chronic Lyme disease can be successfully treated but the success is tempered by the high prevalence and incidence of relapses. If a relapse occurs, a relapse can successfully respond to re-treatment.