Lähettäjä: Soijuv Lähetetty: 6.2.2005 14:14
Skotlannissa esiintyy paljon borrelioosia. Tutkijat ovat löytäneet suurelta osalta tiettyä ihosyöpää (B-solu lymfooma) sairastavia borrelia bakteerin DNA:ta.
Sheep tick can pass rare skin cancer to people
By Tom Peterkin Health Correspondent-
Scotland on Sunday - 9-24-00
SCOTTISH doctors have discovered that the humble sheep tick is responsible for passing a rare but deadly form of skin cancer to humans.
The new research has heralded the prospect of the cancer being tackled by antibiotics instead of more aggressive therapies.
Researchers at Raigmore Hospital in Inverness have identified a link between a B-cell lymphoma skin cancer and bacteria transmitted by the parasitic blood-suckers.
It has been known for some time that the bacterium Borrelia burgdorferi is responsible for passing on Lyme disease to humans. But doctors in Inverness are the first to identify a significant relationship between the tick-borne bacterium, which is a distant cousin of syphilis, and cancer.
Dr John Goodlad of the department of pathology at Raigmore Hospital said: "We knew that because there was a high incidence of Lyme disease in the Highlands if there was going to be a relationship between B-cell lymphoma and cancer, we were going to find it here.
"We did a large number of controls, so we know that it was not just a chance result. Our findings showed a statistically significant association and gave us evidence that the organism was present. This is the first time that the link has been shown in the UK and it is certainly the first British study of this."
It is estimated that the Scottish Highlands has one of the highest rates of Lyme disease in Northern Europe. In the north of Scotland, there are 16 cases per 100,000 people each year.
"But that is probably a gross underestimation," said Goodlad. "It is probably much higher than that, because it is not a notifiable disease. Not all cases are reported and no one has done an epidemiological study to look at it thoroughly."
Borrelia burgdorferi triggers the unpleasant symptoms of Lyme disease such as arthritis, inflammation of the heart and brain, and skin rashes.
The disease took its name from the town of Lyme in Connecticut, where it was first recognised in 1975. Since then it has been recorded all over Europe and North America.
But the new link with skin cancer was only revealed when 20 B-cell lymphoma patients were compared with other skin cancer victims at Raigmore.
The researchers found that a significant number of those with lymphoma carried burgdorferi-specific DNA. The research, which has been published in this month's edition of the American Journal of Surgical Pathology, has already aroused interest in the United States where notices are erected in the countryside to warn people of the dangers of Lyme disease.
BORRELIABAKTEERI/IHOSYÖPÄ
Valvojat: Jatta1001, Borrelioosiyhdistys, Bb
BORRELIABAKTEERI/IHOSYÖPÄ
Viimeksi muokannut Bb, Su Huhti 18, 2010 18:23. Yhteensä muokattu 2 kertaa.
Lähettäjä: Soijuv Lähetetty: 6.2.2005 14:17
Tässä tiivistelmä tutkimuksesta:
Primary cutaneous B-cell lymphoma and Borrelia burgdorferi infection in
patients from the Highlands of Scotland.
Goodlad JR, Davidson MM, Hollowood K, Ling C, MacKenzie C, Christie I,
Batstone PJ, Ho-Yen DO.
Department of Pathology, Raigmore Hospital, Inverness, Scotland, UK.
John.Goodlad@raigmore.scot.nhs.uk
Although a link between primary cutaneous B-cell lymphoma (PCBCL) and
Borrelia burgdorferi infection has long been suspected, previous
studies have not demonstrated a significant association. The authors
looked for evidence of B. burgdorferi in 20 cases of PCBCL from the
Scottish Highlands, an area with endemic Lyme disease, and compared
their findings with those in 40 control patients (20 undergoing wide
reexcision at sites of malignant melanoma and 20 biopsies of
inflammatory dermatoses). All studies were performed on formalin-fixed,
paraffin-embedded tissues. The cases of PCBCL were classified according
to criteria described by the European Organization for Research and
Treatment of Cancer Cutaneous Lymphoma Project Group using a
combination of morphology, immunohistochemistry, and seminested
polymerase chain reaction (PCR) for immunoglobulin heavy chain gene
rearrangement. A nested PCR was performed on deoxyribonucleic acid
(DNA) extracts from the lymphoma and control cases using primers to a
unique conserved region of the B. burgdorferi flagellin gene. B.
burgdorferi-specific DNA was detected in seven of 20 lymphoma cases
(five of 12 marginal zone lymphomas, one of five primary cutaneous
follicle center cell lymphomas, one of three diffuse, large B-cell
lymphomas of the leg) and in one melanoma reexcision patient of 40
control subjects. The relationship between B. burgdorferi and PCBCL was
significant when compared with the control groups separately (p <0.05)
or in combination (p <0.01). These results provide strong evidence to
support the concept of B. burgdorferi-driven lymphomagenesis in the
skin.
PMID: 10976703 [PubMed - indexed for MEDLINE]
Tässä tiivistelmä tutkimuksesta:
Primary cutaneous B-cell lymphoma and Borrelia burgdorferi infection in
patients from the Highlands of Scotland.
Goodlad JR, Davidson MM, Hollowood K, Ling C, MacKenzie C, Christie I,
Batstone PJ, Ho-Yen DO.
Department of Pathology, Raigmore Hospital, Inverness, Scotland, UK.
John.Goodlad@raigmore.scot.nhs.uk
Although a link between primary cutaneous B-cell lymphoma (PCBCL) and
Borrelia burgdorferi infection has long been suspected, previous
studies have not demonstrated a significant association. The authors
looked for evidence of B. burgdorferi in 20 cases of PCBCL from the
Scottish Highlands, an area with endemic Lyme disease, and compared
their findings with those in 40 control patients (20 undergoing wide
reexcision at sites of malignant melanoma and 20 biopsies of
inflammatory dermatoses). All studies were performed on formalin-fixed,
paraffin-embedded tissues. The cases of PCBCL were classified according
to criteria described by the European Organization for Research and
Treatment of Cancer Cutaneous Lymphoma Project Group using a
combination of morphology, immunohistochemistry, and seminested
polymerase chain reaction (PCR) for immunoglobulin heavy chain gene
rearrangement. A nested PCR was performed on deoxyribonucleic acid
(DNA) extracts from the lymphoma and control cases using primers to a
unique conserved region of the B. burgdorferi flagellin gene. B.
burgdorferi-specific DNA was detected in seven of 20 lymphoma cases
(five of 12 marginal zone lymphomas, one of five primary cutaneous
follicle center cell lymphomas, one of three diffuse, large B-cell
lymphomas of the leg) and in one melanoma reexcision patient of 40
control subjects. The relationship between B. burgdorferi and PCBCL was
significant when compared with the control groups separately (p <0.05)
or in combination (p <0.01). These results provide strong evidence to
support the concept of B. burgdorferi-driven lymphomagenesis in the
skin.
PMID: 10976703 [PubMed - indexed for MEDLINE]