BLC - UUSI TUTKIMUSMENETELMÄ NEUROBORRELIOOSIIN

[Bb]

Lähettäjä: Soijuv Lähetetty: 26.8.2005 19:57

Saksalaisessa tutkimuksessa havaittiin neuroborrelioosia sairastavien selkäydinnesteessä kohonneita BLC-arvoja. Mahdollisesti uusi diagnostinen tutkimusmenetelmä:


http://www.ncbi.nlm.nih.gov/entrez/quer ... query_hl=7

Neurology. 2005 Aug 9;65(3):448-50.

The chemokine CXCL13 (BLC): a putative diagnostic marker for neuroborreliosis.

Rupprecht TA, Pfister HW, Angele B, Kastenbauer S, Wilske B, Koedel U.

Department of Neurology, Ludwig-Maximilians University, Munich, Germany.

Using protein expression profiling, the authors identified an upregulation of the chemokine B lymphocyte chemoattractant (BLC) in the CSF of patients with neuroborreliosis but not in patients with noninflammatory and various other inflammatory neurologic diseases. This upregulation was confirmed by ELISA, showing increased BLC levels in every neuroborreliosis patient while being undetectable in patients with noninflammatory neurologic diseases. These results point to BLC as a putative additional diagnostic marker for neuroborreliosis.

PMID: 16087912 [PubMed - in process]