Lähettäjä: Soijuv Lähetetty: 29.9.2005 16:45
Borreliabakteerista on löydetty fluoroquinoloneille (sparfloxacin, moxifloxacin) resistenttejä kantoja:
Antimicrob Agents Chemother. 2005 Oct;49(10):4354-7.
parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi.
Galbraith KM, Ng AC, Eggers BJ, Kuchel CR, Eggers CH, Samuels DS.
Division of Biological Sciences, The University of Montana, 32 Campus Dr.
4824, Missoula, MT 59812-4824. scott.samuels@umontana.edu.
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme
disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit
of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin,
moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first
description of fluoroquinolone resistance in the spirochete phylum.
PMID: 16189120 [PubMed - in process]
BORRELIABAKTEERI VASTUSTUSKYKYINEN
Valvojat: Jatta1001, Borrelioosiyhdistys, Bb