MAGNESIUMIN PUUTETTA BORRELIOOSISSA

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Lähettäjä: Soijuv Lähetetty: 1.1.2006 14:43

Magnesiumin puute heikentää imuunijärjestelmää. Magnesiumin lisääminen näyttäisi stimuloivan immuunijärjestelmää esim. varhaisvaiheen borrelioosissa.

Romanialainen tapausselostus: Potilailla oli päänsärkyä, rytmihäiriöitä, kuumetta, kipuja jne sekä magnesiumin puute. Antibioottihoito ei johtanut toivottuun tulokseen joten hoitoon lisättiin magnesiumia jonka jälkeen heidän vointinsa parani selvästi.


Lyme disease and magnesium deficiency

V. CRISTEA - Department of Immunopathology, Medical Clinic III, "Iuliu Hatieganu"University of Medicine and Pharmacy, MONICA CRIAN - Department of Immunology,"Ion Chiricu" Oncological Institute, Cluj-Napoca, Romania V. CRIAN - ITEM-Paneuro Group. vlaicu@.m@if..c;!ntci,rQ

During the period April 2001 - January 2003, we had under observation two cases, in which the presence of both IgM and IgG antibodies to Borrelia burgdorferi was serologically confirmed at high titers. In both cases, clinical manifestations were similar: shivering, fever, headache, articular and right hypochondrium pain, and objectively - tachycardia and erythema migrans - these elements being important for the formulation of Lyme disease suspicion.

Humoral tests showed: significantly increased ESR, leukocytosis with PMN predominance, intensely positive PCR (for B. Burgdorferi DNA) and significant magnesium deficiency (1.20 mEq/L, 1.33 mEq/L,respectively).

A large spectrum of antibiotics with both oral and parenteral
administration has been so far used in the treatment of Lyme borreliosis. Among the most frequently used are tetracyclines, betalactamides and cephalosporins.

The decision to initiate antibiotic therapy can be difficult because in the majority of the cases acute infection is self-limited. Asymptomatic patients, in whom laboratory examinations sustain the diagnosis of Lyme disease, should be treated in order to prevent infection dissemination.

Since in the first case antibiotic therapy alone did not lead to the expected results, magnesium derivatives were also associated. In both cases, following combined therapy, symptomatology significantly improved at 1 days, and laboratory examinations were restored to normal values after 6-8 weeks - disappearance of IgM to B. Burgdorferi and significantly increased magnesemia (1.74 mEq/L, 1.72 mEq/L, respectively)

We believe that in certain diseases, Mg deficiency can cause a decrease in immune response. The appearance of recurrences, which are frequently reported in the literature, in spite of adequate antibiotic therapy, could represent an argument for this.
This is why the use of Mg derivatrves in therapy can represent an immunostimulating factor.

The peculiarities of the cases are the following:
1. Patients had in addition to fever, articular pain and erythema migrans, Mg deficiency
2. The supplementation of therapy with Mg derrvatives had an immediate beneficial effect that was maintained in time.

As a conclusion at this stage, we consider that in the acute phase of Lyme borreliosis there is a significant Mg consumption and the introduction in therapy of such preparations is recommended and beneficial.