KLAMYDIA KESKUSHERMOSTOSSA

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Lähettäjä: Soijuv Lähetetty: 10.1.2006 13:36

Osalla MS-tautia sairastavista löytyi keuhkoklamydiaa
keskushermostosta:


J Infect Dis. 2005 Oct 1;192(7):1219-28. Epub 2005 Sep 2.

Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.

Sriram S, Ljunggren-Rose A, Yao SY, Whetsell WO Jr.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. subramaniam.sriram@vanderbilt.edu
To examine a possible relationship between Chlamydia pneumoniae infection and multiple sclerosis (MS), we undertook an immunohistochemical (IHC), molecular, and ultrastructural comparison of central nervous system (CNS) tissue and cerebrospinal fluid (CSF) sediment from patients with MS and control individuals with other neurological diseases (ONDs). In 7 of 20 MS cases, IHC staining was seen in association with ependymal surfaces and periventricular regions of formalin-fixed brain tissue, by use of 3 different antichlamydial antibodies. There was no staining with any of the 3 antichlamydial antibodies in formalin-fixed brain tissue from OND controls (n=17). With available frozen CNS tissue, polymerase chain reaction (PCR) studies for the presence of C. pneumoniae genes were performed. The presence of a PCR signal was confirmed in 5 of 8 MS cases and in 3 of 18 OND controls. In an examination of CSF sediment by electron microscopy, we observed electron-dense structures resembling chlamydial organisms in CSF sediments from 11 of 20 MS cases and 2 of 12 OND controls. The presence of immunogold-labeled electron-dense bodies was correlated with the presence of a PCR signal in 10 of 11 MS cases. Results of studies using these different approaches support our suspicion of the presence of chlamydial organisms in the CNS, in a subset of patients with MS.

PMID: 16136465 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/quer ... 6465&query_
hl=1&itool=pubmed_docsum

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Lähettäjä: Soijuv Lähetetty: 26.2.2006 16:22

Keuhkoklamydiaa löydetään lisäinfektiona aika usein myös borrelioosia sairastavilta.


Ideggyogy Sz. 2006 Jan 20;59(1-2):4-16.

The significance of Chlamydia pneumoniae in selected neurologic disorders

[Article in Hungarian]

Horvath Z, Vecsei L.

Szegedi Tudomanyegyetem, Neurologiai Klinika, Szeged.

Chlamydia pneumoniae has recently been implicated in the pathogenesis of
several neurological diseases. As an intracellular parasite with its unusual
life cycle it is able to circumvent the immune system and to persist in the
organism. It has the ability to modify the function of the infected cell and
supposedly induce autoimmune reactions. These properties can make it
pathogenic in several chronic neurological diseases including multiple
sclerosis, atherosclerosis, stroke, Alzheimer dementia and giant cell
arteriitis. The evaluation of the available, often contradictory, data that
are based on various different methods is not easy. The importance of the
issue is enhanced by the potential need for antibiotic treatment.

PMID: 16491568 [PubMed - in process]