ROKOTUS VOI AKTIVOIDA BORRELIOOSIN, MS-TAUDIN JNE.

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Lähettäjä: Soijuv Lähetetty: 29.3.2006 7:57

Tri Cosaron mukaan latentti borrelioosi saattaa aktivoitua normaalin rokotuksen seurauksena. Hän näkee tällaisia tapauksia toistuvasti. Oireet alkavat yleensä noin kahden viikon kuluttua rokotteiden saannista (esim. normaalit lapsuusiän rokotteet). Lopussa on tapausselostus 16-vuotiaasta lapsesta joka sai hepatiitti B -rokotteen ja hänellä puhkesi MS-taudin oireet sen jälkeen.


source: 1996 Boston Conference on Lyme Disease.

Dr. Cosaro is a pediactric infectious disease doctor in Weschester County New York.

"Dr. Cosaro: "I'd like to comment from the point of view of pediatrics. This is something I do see on a regular basis. If you have latent Lyme disease, that's Lyme disease unrecognized and you receive the standard immunizations, your disease can be reactivated instead of quieted......In the rheumatological literature it is well known that if you have active juvenile rheumatoid arthritis, you should not receive any of the standard immunizations DPT, measles, flu shot because these are known to reactivate the arthritis phase of that disease.

The same thing happens in Lyme disease and I've seen a lot of patients who we clearly can state that their symptoms started within 2 weeks of
receiving the measles, mumps, german measles shots, for instance, which is mandatory for 5 year olds in New York before they start kindergarden. I see a number of children present with arthritis, children whose symptoms began within two weeks of receiving that immunization."

"The data from humans and animals is very clear, when you stimulate the
immune system with vaccines you increase the risk of autoimmunity and exacerbate smoldering inflammatory conditions." J. Barthelow Classen, M.D., M.B.A
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http://www.cmj.org/Periodical/PaperList.asp?id=LW8451
Chin Med J (Engl). 2006 Jan 5;119(1):77-9.

Multiple sclerosis after hepatitis B vaccination in a 16-year-old patient.


Since the first description of multiple sclerosis (MS), it has been known
that relapse of the disease may be triggered by febrile infections . 1
Although the prevention of febrile illness is therefore clearly advantageous
for those with MS, there is considerable controversy as to whether vaccine
should be administered to such individuals. A further subject of debate is
the possibility that vaccination (against influenza, or hepatitis B) leads
to the development of MS. The coincidence observed between the
administration of hepatitis B vaccine and the onset or relapse of MS and
other demyelinating diseases 2-5 has stimulated a number of studies of the
possibility of their association . 6-12

Previous case reports found controversial relationship between hepatitis B
vaccination and MS. In the case presented here, the close temporal
association suggested a possible casual link between the encephalomyelitis
episode and hepatitis B vaccination.

CASE REPORT

A 16-year-old female patient was vaccinated against hepatitis B in May 1999.
Neurological symptoms were observed 10 weeks later. There was an insidious
development of weakness in the left arm [ 4/5 Medical Research Council (
MRC ) scale ] and later in the right hand (4/5 MRC scale), and the
neurological examination revealed bilateral proximal weakness in the lower
legs (3/5 MRC scale). The deep tendon reflexes were brisk in all four limbs,
the plantar responses were up-going and abdominal reflexes were absent on
both sides. Sensory loss was noted distally from the Th6 level.

The cerebrospinal fluid ( CSF ) examination revealed an elevated IgG level
(all other CSF results were normal). Enzyme linked immunosorbent assay (
ELISA ) for Borellia (from the serum and CSF) was negative. The brain MRI
demonstrated an inhomogeneous lesion with a hyperintense signal on
T2-weighted images in the lower brainstem (Fig. 1A), and numerous T2
hyperintense lesions measuring 10-20 mm that enhanced gadolinium in the
cervical and thoracic spinal cord (Fig. 1). The diagnostic possibilities
considered acute disseminated encephalomyelitis, collagenosis, sarcoidosis
and a first attack of MS . 13

The patient was treated with intravenous methylprednisolone for 6 days (100
mg/d) and then with intravenous immunoglobulin for 5 days (1 g/kg per day).
Within a few weeks after the therapy, her condition showed a marked
improvement, the remission being almost complete. Four years later the
patient experienced gait abnormalities. The neurological examination
revealed paraparesis (3/5 MRC scale) with a bilateral Babinski response.
Sensory loss was again noted distally from the Th6 level. The brain MRI
demonstrated an inhomogeneous lesion in the lower brainstem, in the same
localization as previously, with acute hyperintense intramedullary lesions
enhancing gadolinium in segments CVII and ThIV-V in positions different from
those observed in the previous examination (Fig. 2). The CSF examination
revealed an elevated Link - index and oligoclonal bands, but no other
abnormalities. Intravenous methylpre - dnisolone therapy for 4 days (100
mg/d) was tried again, but the patient's condition worsened. Flaccid
tetraparesis, burning and painful paraesthesia were present on both sides.
However, treatment with immunoglobulin for 10 times (1 g/kg per day), was
followed by a marked improvement, the remission being almost complete (Fig.
3).

DISCUSSION

Multiple sclerosis is an immune-mediated chronic disorder of the central
nervous system (CNS), characterized by spatial and temporal dissemination of
the pathological process. The pathogenesis is thought to involve an
autoimmune process that occurs in genetically susceptible individuals,
triggered by an exogenous agent.

Since autoimmunity is recognized as being an important factor in MS, it
appears theoretically possible that immunization might play a role in its
pathogenesis. However, a number of large-scale studies have failed to
establish a conclusive relationship between hepatitis B vaccination and MS .
1, 6-9 Although the most recently published findings demonstrated a
statistically significant elevated risk . 11, 12

In the case presented here, a direct casual link between the
encephalomyelitis episode and the hepatitis B vaccination is suggested by
the close temporal association. The controversy between the studies suggests
the need of further investigations of the causality between hepatitis B
vaccination and development of MS.

REFERENCES

1. Merelli E, Casoni F. Prognostic factors in multiple sclerosis: role of
intercurrent infections and vaccinations against influenza and hepatitis B.
Neurol Sci 2000;21 (4 Suppl 2) :S853- S 856.
2. Cabrera-Gomez JA, Echazabal-Santana N, Garcia Gonzalez L, Kamos Cedeno
AM, Rodriguez Roque MO, Lopez Hernandez O, et al. A severe episode in a
patient with reccurent disseminated acute encephalitis due to vaccination
against hepatitis B. For or against vaccination? Rev Neurol 2002;34:358-363.
3. Konstantinou D, Paschalis C, Maraziotis T, Dimopoulos P, Bassaris H,
Skoutelis A . Two episodes of leukoencephalitis associated with recombinant
hepatitis B vaccination in a single patient. Clin Infect Dis
2001;33:1772-1773.
4. Tourbah A, Gout O, Liblau R, Lyoncaen O, Bougniot C, Iba-Zizen MT, et al.
Encephalitis after hepatitis B vaccination: reccurent disseminated
encephalitis or MS? Neurology 1999;53:396-401.
5. Herroelen L, De Keyser J, Ebinger G. Central-nervous system demyelination
after immunisation with recombinant hepatitis B vaccine. Lancet
1991;338:1174-1175.
6. Destefano F, Verstraeten T, Jackson LA, Okoro CA, Benson P, Black SB, et
al. Vaccinations and risk of central nervous system demyelinating diseases
in adults. Arch Neurol 2003;60:504-509.
7. Demicheli V, Rivetti A, Di Pietrantonj C, Clements CJ, Jefferson T .
Hepatitis B vaccinations and multiple sclerosis: evidence from systematic
review. J Viral Hepat 2003;10:343-344.
8. Zipp F, Weil JG, Einh?upl KM. No increase in demyelinating diseases after
hepatitis B vaccination. Nat Med 1999;53: 396-401.
9. Duclos P. Safety of immunization and adverse events following vaccination
against hepatitis B. Expert Opin Drug Saf 2003;2:225-231.
10. Gout O. Vaccination and multiple sclerosis. Neurol Sci 2001;22:151-154.
11. Naismith RT, Cross AH. Does the hepatitis B vaccine cause multiple
sclerosis? Neurology 2004;63:772-773.
12. Hernán MA, Jick SS, Olek MJ, Jick H . Recombinant hepatitis B vaccine
and the risk of multiple sclerosis. Neurology 2004;63:838-842.
13. Atlas SW. Magnetic resonance imaging of the brain and spine . 3rd edi
tion on CD-ROM . Philadelphia : Lippincott, Williams and Wilkins ; 2003.

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Lähettäjä: Kristiina1001 Lähetetty: 29.3.2006 20:45

Hei Soile,

Kiitos mielenkiintoisesta jutusta. Olen kuullut Suomessa siitä, että influenssarokotuksen jälkeen olisi käynyt samoin. Tästä syystä olen miettinyt, missä vaiheessa "uskaltaisin" ottaa Havrix-tehosteen ja päätynyt ottamaan sen nyt, koska menossa on 3 viikon Rocephal-kuuri. Näin siis, jos rokote voidaan nyt antaa.

Oli muuten mielenkiintoista, että kuuria aloitettaessa ollessani osastolla, osastonhoitaja kysyi, olisinko kiinnostunut kuulemaan hänen kivunlievityskeinoistaan. Hän suositteli oman kokemuksensa perusteella karpalomehua sekä viherhuuli-simpukka-inkivääriä. Lisäksi vertailimme kokemuksiamme erilaisen liikunnan vaikutuksesta nivel- ja lihassärkyihin. Todella positiivista, kokonaisvaltaista hoitoa. Keskustelupalstalla olleiden kannanottojen perusteella ilmeisen poikkeuksellista...

Kevät terveisin

Kristiina
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Lähettäjä: Soijuv Lähetetty: 30.3.2006 9:27

Rokotteiden jälkeisestä oireiden puhkeamisesta on kokemuksia ympäri maailmaa. Viime Vuosikokouksessammekin kaksi jäsentämme kertoi Borrelioosioireidensa alkaneen rokotteen jälkeen. En osaa sanoa, milloin olisi turvallista ottaa rokotteita, mutta mikäli sellaisia välttämättä tarvitsee, tuntuisi järkevältä ottaa se antibioottihoidon aikana.

Mainitsemasi valmisteet ja liikunta ovat aika yleisesti käytössä olevia kivunlievitysmenetelmiä. Parempi olisi jos pääsisi eroon kaikista erityisvalmisteista. Emäsvoittoisella ravinnolla (tuoreet vihannekset, marjat, hedelmät) ovat monet niveltulehduksista/reumasta kärsivät saaneet hyviä tuloksia. Hienoa, että osastolla oli henkilö joka osasi ajatella asioita vähän laajemmin.