BAKTEERIT LISÄÄVÄT SYÖPÄRISKIÄ

[soijuv]

Erilaiset bakteerit kuten bartonella, helikobakteeri ym. krooniset infektiot voivat aiheuttaa syövän (UK 2002):

How bacteria could cause cancer: one step at a time.Trends Microbiol. 2002; 10(6):293-9 (ISSN: 0966-842X)Lax AJ; Thomas WDept of Oral Microbiology, King's College London, Guy's Hospital, London, UK. alistair.lax@kcl.ac.uk

Helicobacter pylori highlighted the potential for bacteria to cause cancer. It is becoming clear that chronic infection with other bacteria, notably Salmonella typhi, can also facilitate tumour development. Infections caused by several bacteria (e.g. Bartonella spp., Lawsonia intracellularis and Citrobacter rodentium) can induce cellular proliferation that can be reversed by antibiotic treatment. Other chronic bacterial infections have the effect of blocking apoptosis. However, the underlying cellular mechanisms are far from clear. Conversely, several bacterial toxins interfere with cellular signalling mechanisms in a way that is characteristic of tumour promoters. These include Pasteurella multocida toxin, which uniquely acts as a mitogen, and Escherichia coli cytotoxic necrotizing factor, which activates Rho family signalling. This leads to activation of COX2, which is involved in several stages of tumour development, including inhibition of apoptosis. Such toxins could provide valuable models for bacterial involvement in cancer, but more significantly they could play a direct role in cancer causation and progression. Major Subject Heading(s) Minor Subject Heading(s) CAS Registry / EC Numbers Adenosine Triphosphatases [metabolism] ApoptosisBacteria [pathogenicity] Bacterial Infections [complications] [epidemiology] [immunology] Bacterial Proteins [metabolism] Bacterial Toxins [metabolism] Bartonella [metabolism] [pathogenicity] Cell DivisionHumansModels, BiologicalNeoplasms [epidemiology] [immunology] [microbiology] Signal Transduction0 (Bacterial Proteins) 0 (Bacterial Toxins) EC 3.6.1.- (Adenosine Triphosphatases) EC 3.6.1.- (rho-ATPase) PreMedline Identifier: 12088666From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine</HTML>