ANTIBIOOTTIHOITO EI TEHOA BORRELIABAKTEERIIN KUNNOLLA

[soijuv]

"Tutkimuksen tulokset (2010) vahvistavat useita aiempia esim. keftriaksonella tehtyjä tutkimuksia joissa eri antibioottien on todettu olevan kykenemätttömiä tuhoamaan kaikkia borreliabakteereja. Bakteerit olivat nähtävissä ja infektiota aiheuttavia mutta ne eivät jakautuneet tai jakautuivat hitaasti."

Tutkimuksessa hiirille annettiin uutta tigesykliini-antibioottia. Hiiret olivat sairastaneet borrelioosia joko viikon, 3 viikkoa tai 4 kuukautta. Infektiotilannetta seurattiin kolmen kuukauden kuluttua hoidosta esim. nivelistä ja sydämestä. Osa hiiristä sai matala-, osa korkea-annoksista antibioottihoitoa.

Suom. huom. keftriaksoni on antibiootti jota annetaan Suomessa yleisesti suonensisäisesti esim. neuroborrelioosi-tapauksissa.

Huom. Jäsensivuilta löytyy borrelioosin hoidosta runsaasti tutkimuksia ja erilaisia hoitoprotokollia ja käyttäjäkokemuksia.


Antimicrob Agents Chemother. 2010 Feb;54(2):643-51. Epub 2009 Dec 7.

Ineffectiveness of tigecycline against persistent Borrelia burgdorferi.

Barthold SW, Hodzic E, Imai DM, Feng S, Yang X, Luft BJ.

Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA. swbarthold@ucdavis.edu

The effectiveness of a new first-in-class antibiotic, tigecycline (glycylcycline), was evaluated during the early dissemination (1 week), early immune (3 weeks), or late persistent (4 months) phases of Borrelia burgdorferi infection in C3H mice. Mice were treated with high or low doses of tigecycline, saline (negative-effect controls), or a previously published regimen of ceftriaxone (positive-effect controls). Infection status was assessed at 3 months after treatment by culture, quantitative ospA real-time PCR, and subcutaneous transplantation of joint and heart tissue into SCID mice. Tissues from all saline-treated mice were culture and ospA PCR positive, tissues from all antibiotic-treated mice were culture negative, and some of the tissues from most of the mice treated with antibiotics were ospA PCR positive, although the DNA marker load was markedly decreased compared to that in saline-treated mice. Antibiotic treatment during the early stage of infection appeared to be more effective than treatment that began during later stages of infection. The viability of noncultivable spirochetes in antibiotic-treated mice (demonstrable by PCR) was confirmed by transplantation of tissue allografts from treated mice into SCID mice, with dissemination of spirochetal DNA to multiple recipient tissues, and by xenodiagnosis, including acquisition by ticks, transmission by ticks to SCID mice, and survival through molting into nymphs and then into adults. Furthermore, PCR-positive heart base tissue from antibiotic-treated mice revealed RNA transcription of several B. burgdorferi genes.

These results extended previous studies with ceftriaxone, indicating that antibiotic treatment is unable to clear persisting spirochetes, which remain viable and infectious, but are nondividing or slowly dividing.


http://www.ncbi.nlm.nih.gov/pubmed/1999 ... dinalpos=1