GLUTATIOONI - KROONISET SAIRAUDET

[Bb]

Lähettäjä: Soijuv Lähetetty: 4.5.2004 11:00

Glutatiooni (proteiini, antioksidantti) osallistuu esim. rasvaliukoisten toksiinien poistoon elimistöstä (esim. raskasmetallit).Tulehduksellisissa kroonisissa taudeissa glutatioonin määrä on alhainen. Glutatioonin määrää elimistössä voi lisätä parhaiten syömällä tuoreita vihanneksia ja hedelmiä. Keitetyissä vihanneksissa sitä ei ole juuri lainkaan. Erityisen paljon sitä on esim. saksanpähkinöissä ja avokadossa.


How to Boost Glutathione Levels

1:15:2003

Glutathione is a small protein composed of three amino acids - cysteine, glutamic acid, and glycine - that is involved in detoxification and antioxidant mechanisms. Many toxins are dealt with by "handcuffing" the toxin to another molecule so it can be escorted out of the body. The process of adding one molecule to another is called conjugation. Glutathione is one of the most important conjugating compounds in helping the body eliminate fat-soluble toxins such as heavy metals, solvents, and pesticides to transform them into a water-soluble form allowing more efficient excretion via the kidneys.

Health Benefits

The combination of detoxification and free radical protection results in glutathione being one of the most important cancer and aging fighters in our cells. Dietary glutathione intake is associated with protection against some forms of cancer.1,2

The greater the exposure to toxins, the faster the body uses up its supply of glutathione. Without the protection of glutathione, cells die at a faster rate, making people age quicker and putting them at risk for toxin-induced diseases including cancer.

People who smoke, are chronically exposed to toxins, suffer from inflammatory conditions such as rheumatoid arthritis, or suffer from chronic conditions like diabetes, AIDS or cancer typically have lower levels of glutathione. It's a vicious cycle: health problems deplete the supply of glutathione, and reduced levels of glutathione increase the risk of health problems.

In addition to its dietary role in enhancing detoxification and protecting against cancer, studies using intravenous glutathione have found it to be useful in: preventing clot formation during operations,3 reducing the side effects and efficacy of chemotherapy drugs like cisplatin,4,5 Parkinson's disease,6 and increasing sperm counts in men with low sperm counts.7,8 A small study in eight patients with liver cancer showed modest effects when given at a daily dosage of 5,000 mg orally.12 Whether increasing dietary intake with glutathione is effective in these conditions is unknown at this time

Dietary Glutathione is Better than Supplements

Don't look to expensive supplements containing glutathione to boost levels of glutathione in the body. While dietary forms of glutathione appear to be efficiently absorbed into the blood, the same does not appear to be true for glutathione supplements in humans. When healthy subjects were given a single dose of up to 3,000 mg of glutathione researchers found there was no increase in blood glutathione levels.11 The authors of the study concluded "it is not feasible to increase circulating glutathione to a clinically beneficial extent by the oral administrating of a single dose of 3 g of glutathione." In contrast, blood glutathione levels rose nearly 50% in healthy individuals taking 500 mg of vitamin C.12 Vitamin C raises glutathione by helping the body manufacture it. In addition, to vitamin C, dietary sources of glutathione and several other nutritional compounds can help increase glutathione levels including N-acetylcysteine (NAC), alpha-lipoic acid, glutamine, methionine, and whey protein. Also, vitamin B6, riboflavin, and selenium are required in the manufacture of glutathione.

As far as foods go, fresh fruits and vegetables provide excellent levels of glutathione, but cooked foods contained far less.10 Asparagus, avocado, and walnuts are particularly rich dietary sources of glutathione.

Table 1. Comparison of Glutathione in Fresh vs. Cooked Foods
Glutathione amount (dry weight)
(in milligrams per 31/2 oz (100 g) serving)

Food Uncooked Cooked
Apples 21 0.0
Carrots 74.6 0.0
Grapefruit 70.6 0.0
Spinach 166 27.1
Tomatoes 169 0.0


For more information on Liver Health, go to
http://www.doctormurray.com/articles/pd ... Health.pdf

*/Key References:/*

1. Sen CK. Nutritional biochemistry of cellular glutathione. Nutr
Biochem 1997;8:660-72.
2. Flagg EW, Coates RJ, Jones DP, et al. Dietary glutathione intake
and the risk of oral and pharyngeal cancer. Am J Epidemiol
1994;139:453-65.
3. Molloy J, Martin JF, Baskerville PA, et al. S-nitrosoglutathione
reduces the rate of embolization in humans. Circulation
1998;98(14):1372-5
4. Smyth JF, Bowman A, Perren T, et al. Glutathione reduces the
toxicity and improves quality of life of women diagnosed with
ovarian cancer treated with cisplatin: results of a double-blind,
randomised trial. Ann Oncol 1997;8(6):569-73.
5. Cascinu S, Cordella L, Del Ferro E, et al. Neuroprotective effect
of reduced glutathione on cisplatin-based chemotherapy in advanced
gastric cancer: a randomized double-blind placebo-controlled
trial. J Clin Oncol 1995;13(1):26-32.
6. Sechi G, Deledda MG, Bua G, et al. Reduced intravenous glutathione
in the treatment of early Parkinson's disease. Prog
Neuropsychopharmacol Biol Psychiatry 1996;20(7):1159-70.
7. Lenzi A, Picardo M, Gandini L, et al. Glutathione treatment of
dyspermia: effect on the lipoperoxidation process. Hum Reprod
1994;9(11):2044-50.
8. Lenzi A, Culasso F, Gandini L, et al. Placebo-controlled,
double-blind, cross-over trial of glutathione therapy in male
infertility. Hum Reprod 1993;8(10):1657-62.
9. Dalhoff K, Ranek L, Mantoni M, Poulsen HE. Glutathione treatment
of hepatocellular carcinoma. Liver 1992;12:341-3.
10. Jones DP, Coates RJ, Flagg EW, et al. Glutathione in foods listed
in the National Cancer Institutes Health Habits and History Food
Frequency Questionnaire. Nutr Cancer 1995;17:57-75.
11. Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic
availability of oral glutathione. Eur J Clin Pharmacol
1992;43(6):667-9.
12. Johnston CJ, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood
cell glutathione in healthy adults. Am J Clin Nutr 58:103-5, 1993.
13. Miglio F, et al. Efficacy and safety of oral betaine glucuronate
in non-alcoholic steatohepatitis. Arzneim Forsch 2000;8:722-7.
14. Miglio F, et al. Efficacy of glucuronates versus placebo in
chronic hepatitis: A randomized, double-blind study. Advances
Therapy 1995;12:299-312.

© 2003 www.doctormurray.com
Reprinted with permission.

http://www.vitaminexpress.com/drmurray/ ... levels.htm