C6 TESTI

[Bb]

Lähettäjä: Soijuv Lähetetty: 28.11.2004 16:31

Tässä tutkimuksessa C6 vasta-ainetesti ei kyennyt osoittamaan onko henkilöllä aktiivinen infektio meneillään:


Eur J Clin Microbiol Infect Dis. 2004 Aug;23(8 ):615-8. Epub 2004 Jul 08.

Pre-treatment and post-treatment assessment of the C(6) test in patients with persistent symptoms and a history of Lyme borreliosis.

Fleming RV, Marques AR, Klempner MS, Schmid CH, Dally LG, Martin DS, Philipp MT.

Department of Medicine, Boston University Medical Center, 650 Albany Street, Room 620, Boston, MA 02118, USA.

It was recently reported that antibody to C(6), a peptide that reproduces an invariable region of the VlsE lipoprotein of Borrelia burgdorferi, declined in titer by a factor of four or more in a significant proportion of patients after successful antibiotic treatment of acute localized or disseminated Lyme borreliosis. The present study evaluated the C(6) test as a predictor of therapy outcome in a population of patients with post-treatment Lyme disease syndrome. The serum specimens tested were from patients with well-documented, previously treated Lyme borreliosis who had persistent musculoskeletal or neurocognitive symptoms. All of the patients had participated in a recent double-blind, placebo-controlled antibiotic trial in which serum samples were collected at baseline and 6 months thereafter, i.show $132#e. 3 months following treatment termination. In this patient population no correlation was found between a decline of C(6) antibody titer of any magnitude and treatment or clinical outcome. Antibodies to C(6) persisted in these patients with post-treatment Lyme disease syndrome following treatment, albeit at a markedly lower prevalence and titer than in untreated patients with acute disseminated Lyme disease. The results indicate that C(6) antibody cannot be used to assess treatment outcome or the presence of active infection in this population.

Publication Types:

* Clinical Trial
* Randomized Controlled Trial


PMID: 15243815 [PubMed - indexed for MEDLINE]