BORRELIOOSISTA NEUROBORRELIOOSIKSI

[soijuv]

Artikkelissa selvitetään niitä mekanismeja, jotka johtavat akuutin borrelioosin kehittymisen neuroborrelioosiksi, sekä sitä miten bakteeri aiheuttaa tulehdustilan keskushermostossa.

The Pathogenesis of Lyme Neuroborreliosis: From Infection to Inflammation

http://www.pubmedcentral.nih.gov/articl ... d=18097481

Mol Med. 2008 Mar?Apr; 14(3-4): 205?212.
Published online 2007 December 13. doi: 10.2119/2007-00091.Rupprecht. PMCID: PMC2148032

Copyright 2008, The Feinstein Institute for Medical Research
The Pathogenesis of Lyme Neuroborreliosis: From Infection to Inflammation
Tobias A Rupprecht,1 Uwe Koedel,1 Volker Fingerle,2 and Hans-Walter Pfister1
1 Department of Neurology, Ludwig-Maximilians University, Munich, Germany
2 Department of Microbiology, Ludwig-Maximilians University, Munich, Germany
Address correspondence and reprint requests to Hans-Walter Pfister, Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, D-81377 Munich, Germany. Phone: +49 89 7095-3676; Fax: +49 89 7095-6673; E-mail: hans-walter.pfis-ter@med.uni-muenchen.de.
Received September 24, 2007; Accepted December 10, 2007.

This review describes the current knowledge of the pathogenesis of acute Lyme neuroborreliosis (LNB), from invasion to inflammation of the central nervous system. Borrelia burgdorferi (B.b.) enters the host through a tick bite on the skin and may disseminate from there to secondary organs, including the central nervous system. To achieve this, B.b. first has to evade the hostile immune system. In a second step, the borrelia have to reach the central nervous system and cross the blood?brain barrier. Once in the cerebrospinal fluid (CSF), the spirochetes elicit an inflammatory response. We describe current knowledge about the infiltration of leukocytes into the CSF in LNB. In the final section, we discuss the mechanisms by which the spirochetal infection leads to the observed neural dysfunction. To conclude, we construct a stringent concept of the pathogenesis of LNB.