SPIROKEETTOJA SUOLISTOSSA

[Bb]

Lähettäjä: Soijuv Lähetetty: 9.5.2005 17:07

Tutkimuksen 15 henkilöltä löytyi suuria määriä spirokeettoja suolistosta. Henkilöillä esiintyi suolistovaivoja, esim. ripulia:


http://www.blackwell-synergy.com/servle ... rochete%29

Colorectal Disease
Volume 4 Issue 2 Page 97 - March 2002
doi:10.1046/j.1463-1318.2002.00284.x

Original article
Intestinal spirochetosis: clinicopathological features with review of the literature
N. Alsaigh1 & F. Fogt2

Objective

The purpose of this study is to evaluate the clinical presentation of patients with intestinal spirochetosis, as it is has not been well described in the literature.

Methods

We studied 15 patients with colonic biopsies that showed spirochetosis. The study group consisted of 11 males and 4 females, 10 of the males were heterosexual and one was homosexual. None of these patients were clinically immunocompromized. A colonoscopy was performed for evaluation of different symptoms. The histological diagnosis of spirochetosis was made on H&E examination and confirmed by Giemsa and/or Steiner stain. There was no evidence of associated active or any specific colitis in any of the cases. The control group consisted of 30 patients, 16 males and 14 females that were matched for age and clinical indications for obtaining a colonic biopsy.

Results

Colonic mucosa with prominent brush border-like surface colonized with large amounts of spirochetes was noted in all 15 cases in the study group and in none of 30 cases in the control group. The clinical presentation in patients with spirochetosis was compared to the control group. Of the spirochetosis patients 86% presented with some form of clinical symptoms compared with 13% of controls. These symptoms included chronic watery diarrhoea in 40% spirochetosis patients vs 5% in controls; a change in bowel habit was present in 33% of spirochetosis patients vs 3.3% in controls. The endoscopic appearance in spirochetosis patients was reported as normal in six patients, `polyoid' in seven patients, erythematous in one patient and `lesion' in one patient.

Conclusion

These findings suggest that colonic spirochetosis affects a heterogenous group of patients, the majority of whom presented with gastrointestinal symptoms. The variable clinical findings may be related to the infecting organism and the condition may not be harmless in all patients.