ALS-TAUTI/KROONINEN BORRELIOOSI

[Bb]

Lähettäjä: Soijuv Lähetetty: 8.9.2005 18:05

Tutkimuksia borreliabakteerin ja puutiaisaivokuumeviruksen yhteydestä ALS-tautiin. Joissakin tapauksissa antibioottihoidosta oli selkeää hyötyä:


Zh Nevropatol Psikhiatr Im S S Korsakova 1983;83(8 ):1173-9

Structure of progressive forms of tick-borne encephalitis
[Article in Russian]
Umanekii KG, Dekonenko EP.

On the basis of long-term follow up (from 2 to 22 years) of 175 patients with various syndromes of progressive forms of tick-borne encephalitis (TBE), evaluation criteria of TBE progression are systematized. Two basic forms of disease progression are identified: amyotrophic and hyperkinetic, each of them breaking down into a series of leading syndromes. Important for characterizing progressive forms of tick-borne encephalitis (PFTBE) are the time when the disease began to progress and the pattern of progression as well as its stage and severity. PFTBE are correlated with the acute period syndromes. In long-term follow-up, 68% of patients with PFTBE display transformation of clinical forms of the disease, with the formation of the lateral amyotrophic sclerosis syndrome in the overwhelming majority of these patients.

PMID: 6414202 [PubMed - indexed for MEDLINE]


J Neurol 1975 Dec 2;211(1):11-23 Related Articles, Books, LinkOut
An uncommon case of amyotrophic lateral sclerosis with isolation of a virus from the CSF.
Muller WK, Hilgenstock F.

An atypical case of amyotrophic lateral sclerosis (ALS) is described, characterized by early manifestation, a long lasting course with asymmetry of the lesions, absence of bulbar symptoms in the presence of an otherwise very advanced symptomatology, and constant signs of an inflammatory reaction in the CSF which was the reason to initiate extensive virological studies, including procedures for virus isolation. A virus belonging to the TbE complex of arbovirus group B (tick-borne flavivures), was finally isolated from the CSF.

About 70% of the ALS cases in Hamburg/W. Germany, examined for antibodies, apparently had contact with this virus. The antibody pattern found made it possible to explain this exceptional case.

PMID: 56428 [PubMed - indexed for MEDLINE]


Wien Med Wochenschr. 1995;145(7-8 ):186-8. Related Articles, Links

ALS-like sequelae in chronic neuroborreliosis

[Article in German]

Hansel Y, Ackerl M, Stanek G.

Neurologischen Abteilung des Kaiser-Franz-Josef-Spitals, Wien.

CSF investigation in a 61-year old female patient with clinical picture of motoneuron disease gave evidence for chronic infection with Borrelia burgdorferi. Improvement of clinical and CSF findings could be observed after antibiotic therapy. The diagnosis of amyotrophic lateral sclerosis which was initially suspected had to be revised and the disorder was interpreted as chronic neuroborreliosis.

Publication Types:
Case Reports

PMID: 7610670 [PubMed - indexed for MEDLINE]


Arch Neurol. 1990 May;47(5):586-94.

Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease.

Halperin JJ, Kaplan GP, Brazinsky S, Tsai TF, Cheng T, Ironside A, Wu P,
Delfiner J, Golightly M, Brown RH, et al.

Department of Neurology, State University of New York, Stony Brook 11794.

Of 19 unselected patients with the diagnosis of amyotrophic lateral sclerosis (ALS) living in Suffolk County, New York (an area of high Lyme disease prevalence), 9 had serologic evidence of exposure to Borrelia burgdorferi; 4 of 38 matched controls were seropositive. Eight of 9 seropositive patients were male (8 of 12 male patients vs 2 of 24 controls). Rates of seropositivity were lower among patients with ALS from nonendemic areas. All patients had typical ALS; none had typical Lyme disease. Cerebrospinal fluid was examined in 24 ALS patients--3 (all with severe bulbar involvement) appeared to have intrathecal synthesis of anti-B burgdorferi antibody. Following therapy with antibiotics, 3 patients with predominantly lower motor neuron abnormalities appeared to improve, 3 with severe bulbar dysfunction deteriorated rapidly, and all others appeared unaffected. There appears to be a statistically significant association between ALS and immunoreactivity to B burgdorferi, at least among men living in hyperendemic areas.

Publication Types:
Case Reports

PMID: 2334308 [PubMed - indexed for MEDLINE]


Acta Virol. 1991 Sep;35(5):458-63. Related Articles, Links

Development of antibodies to axonal neurofilaments in the progression of chronic tick-borne encephalitis.

Fokina GI, Roikhel VM, Magaznik SS, Volkova LI, Frolova TV, Pogodina VV.

Institute of Poliomyelitis and Viral Encephalitides, AMS U.S.S.R., Moscow.

We followed the presence of autoantibodies to neurofilaments (NF) in the sera of patients with acute tick-borne encephalitis (TBE), chronic TBE, amyotrophic lateral sclerosis (ALS), and other diseases of CNS. The diagnosis was made according to clinical signs and based on virus neutralizing antibodies.

Autoantibodies to NF were found in the majority of chronic TBE patients during disease progression, but were neither present in acute TBE nor in chronic TBE cases during the stabilization phase. Autoantibodies to NF found in a patient with acute TBE showed subsequent progression to a prolonged course. The data are discussed in order to assess the mechanisms of the chronic TBE process and its role in impairing the slow axonal transport.

PMID: 1688079 [PubMed - indexed for MEDLINE]


Zh Nevropatol Psikhiatr Im S S Korsakova. 1970;70(8 ):1124-9. Related
Articles, Links

The relationship between amyotrophic lateral sclerosis and tick-born encephalitis

[Article in Russian]

Protas II, Votiakov VI.

PMID: 5504880 [PubMed - indexed for MEDLINE]


Zh Nevrol Psikhiatr Im S S Korsakova. 2001;101(4):10-5. Related Articles,
Links


Clinical pathogenic peculiarities of chronic Russian tick-born encephalitis

[Article in Russian]

Nadezhdina MV.

Clinical, serologic, epidemiological and neurological studies were carried out in 23 patients (18 men, 5 women) aged 15-69 years who had chronic Russian tick-borne encephalitis (RTE). With permanent stable humoral immunity the fact that these forms might develop was confirmed in 73.9% of the cases. In 26.1% of the patients were found to have incomplete vaccination and vaccine therapy combined with RTE viral infection. The following conditions underlay chronization were observed in all forms of acute RTE: fever in 4.3%, meningitis in 30.4%, focal lesion in 43.5% (the encephalitic syndrome in 8.7%, poliomyelitis in 8.7%, encephalopoliomyelitis in 26.1%). Initially progressive course was found in 21.7% of the cases. There was a primary rise of the hyperkinetic syndrome after the meningeal and focal forms of RTE with the encephalitic syndrome; while development of the amyotrophic syndrome (ATS) was found after the focal form with the poliomyelitic and encephalopoliomyelitic syndrome. The amyotrophic lateral sclerosis (ALS) syndrome occurs as both primary progressive RTE and ATS transformation independently of the initial RTE form. Latent periods of development of ATS and ALS syndrome were virtually equal (mean 1.4 years) and did not depend on the initial form of acute RTE. The duration of development of latent chronic forms makes it necessary to follow up RTE patients for at least 3 years.

PMID: 11490426 [PubMed - indexed for MEDLINE]