BB:N SELVIYTYMISMEKANISMIT

[Bb]

Lähettäjä: Soijuv Lähetetty: 6.9.2004 10:54

Science. 2000 Jun 2;288(5471):1651-3.

Elimistö puolustautuu mikrobeja vastaan
mm. rajoittamalla raudan määrää - Bb
selviytyy tästäkin, sillä se ei tarvitse rautaa
muiden mikrobien
tavoin.


Lack of a role for iron in the Lyme disease pathogen.
Posey JE, Gherardini FC.
Department of Microbiology, University of Georgia, Athens, GA
30602, USA.

A fundamental tenet of microbial pathogenesis is that bacterial
pathogens must overcome host iron limitation to establish a
successful infection. Surprisingly, the Lyme disease pathogen
Borrelia burgdorferi has bypassed this host defense by
eliminating the need for iron. B. burgdorferi grew normally and
did not alter gene expression in the presence of iron chelators.
Furthermore, typical bacterial iron-containing proteins were not
detected in cell lysates, nor were the genes encoding such
proteins identified in the genome sequence. The intracellular
concentration of iron in B. burgdorferi was estimated to be less
than 10 atoms per cell, well below a physiologically relevant
concentration.