TULEHDUKSET ERI SAIRAUKSIEN YHTEYDESSÄ

[Bb]

Lähettäjä: Soijuv Lähetetty: 13.12.2004 14:13

Seuraavassa artikkelissa käsitellään tulehdusten osuutta eri sairauksissa. Artikkeli keskittyy syöpään mutta sopii myös esim. autoimuunisairauksiin jne. Mielenkiintoista artikkelissa on osio jossa kerrotaan reniini-angiotensiini -systeemin osuudesta tulehduksissa. Aihe liittyy keskustelupalstalla aiemmin olleisiin artikkeleihin Marshallin protokollasta. AT 1 esto saattaisi artikkelin mukaan tarjota hoidon esim. bakteerien aiheuttamien kroonisten tulehdustilojen hoitoon. (Marshall käyttää hoitoon Olmesartania ja matala-annoksista antibioottia).


http://www.journal-inflammation.com/content/1/1/3 The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.

--- In the renin-angiotensin system, the angiotensin II receptors AT1 and AT2 seem to have opposing functions. The actions of AT1 being principally pro-inflammatory whilst AT2 provides protection against hypoxia, draws inflammatory action to a close and promotes healing. The various direct and indirect mechanisms for feedback between the receptors, their induced products and the external hormonal system in the control of inflammation and healing are summarised in a highly simplified model which none the less can be used to explain how many key promoters and inhibitors of disease exert their effects.

From a review of the current disease literature, it has been demonstrated that the role of AT1 and AT2 in inflammation is not limited to cancer-associated inflammation, but is generally consistent and system wide. Potential therapy by manipulation of these receptors, although at an early stage, has been demonstrated for some of these diseases and it is proposed that this approach will provide an effective basis for the treatment of autoimmune, inflammatory and neurodegenerative disorders using existing drugs. AT1 receptor blockade should, in addition, provide a treatment to alleviate the damage caused by bacterial and viral infections, where their destructive action is through chronic inflammation. Given the importance of the immune suppressant effect of inflammation in cancer, it is anticipated that AT1 blockade should also serve to elicit a more effective immune response to other invaders that seek to corrupt the wound recovery process.

Manipulation of the AT1 and AT2 receptors has profound and exciting implications in the control of disease.