GLUTATIONI

[Bb]

Lähettäjä: Soijuv Lähetetty: 31.5.2005 11:28

Glutationia on suositeltu useissa lähteissä erilaisiin
keskushermostosairauksiin mm. osana borrelioosin
hoitoa. Seuraavan tutkimuksen mukaan glutationi
saattaisi olla hyödyllistä myös Parkinsonin taudissa:


"Proc Natl Acad Sci U S A. 2005 May 23; [Epub ahead of print]

Increased glutathione S-transferase activity rescues dopaminergic
neuron loss in a Drosophila model of Parkinson's disease.

Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ.

Department of Genome Sciences, University of Washington School of
Medicine, Seattle, WA 98195; Elan Pharmaceuticals, 800 Gateway
Boulevard, South San Francisco, CA 94080.

Loss-of-function mutations of the parkin gene are a major cause of
early-onset parkinsonism. To explore the mechanism by which loss of
parkin function results in neurodegeneration, we are using a genetic
approach in Drosophila. Here, we show that Drosophila parkin mutants
display degeneration of a subset of dopaminergic (DA) neurons in the
brain. The neurodegenerative phenotype of parkin mutants is enhanced
by loss-of-function mutations of the glutathione S-transferase S1
(GstS1) gene, which were identified in an unbiased genetic screen for
genes that modify parkin phenotypes. Furthermore, overexpression of
GstS1 in DA neurons suppresses neurodegeneration in parkin mutants.
Given the previous evidence for altered glutathione metabolism and
oxidative stress in sporadic Parkinson's disease (PD), these data
suggest that the mechanism of DA neuron loss in Drosophila parkin
mutants is similar to the mechanisms underlying sporadic PD.
Moreover, these findings identify a potential therapeutic approach in
treating PD."