SUOLAVETTÄ HENGITYSTEIDEN TULEHDUKSIIN

[Bb]

Lähettäjä: Soijuv Lähetetty: 21.1.2006 11:05

Suolavesi näyttää tutkimusten mukaan olevan tehokas hoitomuoto keuhkojen infektiotautien hoidossa. Tutkimuksessa potilas sairasti kystistä fibroosia. Hän hengitti vähintään kaksi kertaa päivässä laimeaa suolavettä. Hoito vähensi oireita, lisäsi liman poistumista ja paransi keuhkojen topimivuutta huomattavasti. Tutkimuksen mukaan hengitysteiden kostuttaminen on elintärkeää hengitysteiden sairauksissa.

Päättelimme että hengitysteiden pinnalla oli liian vähän kosteutta jotta ne voisivat puhdistua limasta. Hämmästykseksemme pelkkä suolavesi oli tehokkaampaa kuin suolavesi, johon oli lisätty kosteutta säilyttävää lääkeainetta (amiloride).


http://www.medpagetoday.com/InfectiousD ... lu/tb/2510

CHAPEL HILL, N.C., Jan. 18 - Salt water, one of the world's most
plentiful commodities, can improve mucus clearance and lung function in
patients with cystic fibrosis -- a goal that has eluded the
pharmaceutical industry.

A pair of studies from researchers here and a team in Sydney, Australia,
provided clinical evidence that inhaled hypertonic saline at least twice
a day can reduce pulmonary exacerbations by 56% (P=0.02), accelerate
mucus clearance, and improve lung function.
Moreover, the finding, published in the Jan. 19 issue of the /New
England Journal of Medicine/, provided clinical proof that re-hydration
of the lungs is a key factor in improving mucus clearance, a theory that
has been hotly debated among cystic fibrosis researchers...

That such a cheap treatment should prove so effective stunned even the
researchers. "What is really surprising is that this is the exact
opposite of our hypothesis," said Dr. Donaldson.

Dr. Donaldson and colleagues have been investigating the mechanism of
cystic fibrosis infections for years. "The hypothesis that we were
working on involved ion transport abnormalities," he said. "We believed
that there was too little fluid on top of the airway surfaces and this
impaired the ability of the lungs to clear mucus."

But he and his colleagues did not think that hypertonic saline by itself
would provide a sustained hydration effect in the lungs, so they
hypothesized that they needed a second drug-amiloride-to sustain the
hydration effect of inhaled 7% sodium chloride.

"We found exactly the opposite. The patients who received just the
hypertonic saline got all the benefit, while the patients who underwent
pre-treatment with amiloride had no improvement," Dr. Donaldson said in
an interview. "We were blown away by this finding and it sent us
scurrying back to the lab where we discovered a novel property of
amiloride-it blocked water transport from the blood....